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MetabolomicsMulti-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L.) Exposed to Water Deficit (Carotenoids; UPLC-DAD assay)

Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids...

2021-08-16 | MTBLS984 | MetaboLights
MetabolomicsMulti-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L.) Exposed to Water Deficit (Phenolics; UPLC-MS/MS assay)

Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids...

2019-04-07 | MTBLS898 | MetaboLights
MetabolomicsMulti-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L.) Exposed to Water Deficit (Volatile organic compounds; SPME-GC-MS assay)

Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids...

2021-08-16 | MTBLS982 | MetaboLights
MetabolomicsRcrR: A Multifunctional Transcriptional Regulator Orchestrating the cariogenic virulence of Streptococcus mutans

We systematically investigated RcrR's contribution to cariogenic virulence using isogenic wild-type, DeltarcrR deletion mutant, and complemented strains. We assessed bacterial growth, biofilm architecture, acid tolerance, and H+-ATPase activity. To delineate the global regulatory network, we inte...

2026-08-06 | MTBLS15272 | MetaboLights
MetabolomicsIntegrated transcriptome and metabolome profiling unveils the tolerance network to potassium deficiency in wild soybean ecotypes

Facing the severe challenge of global soil potassium deficiency on crop production, two different ecological row types of wild soybean [ Glycine soja sieb. & Zucc. In order to reveal the physiological and molecular mechanisms of tolerance to low potassium stress in glycine soja, we compared t...

2025-07-22 | MTBLS12758 | MetaboLights
MetabolomicsMetabolostasis failure thresholds are linked with network topology, metabolite solubility, and translational control

Cells maintain metabolite homeostasis (metabolostasis) by buffering fluctuations in metabolite levels, yet the limits of this buffering and the mechanisms underlying metabolic toxicity remain poorly understood. To study this, we systematically overfed metabolites in Saccharomyces cerevisiae and q...

2026-09-29 | MTBLS12080 | MetaboLights
GenomicsMINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells
Despite the established role of the transcription factor MYC in cancer, little is known about the involvement of lncRNAs in mediating MYC’s function. Here we have intersected RNA-sequencing data from MYC-inducible cell lines, from a cohort of 91 mature B-cell lymphomas and from sorted germinal-cente...
EGAS00001001199 | EGA
ProteomicsMediator complex interaction partners organize the transcriptional network that defines neural stem cells
Mediator complex regulates transcription by connecting enhancers to promoters. High Mediator binding density defines super enhancers, which regulate cell-identity genes and oncogenes. Protein interactions of Mediator may explain its role in these processes but have not been identified comprehensivel...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-06 | PXD013546 | Pride
Neural stem cells Mediator Transcriptional network 
TranscriptomicsDeciphering genomic alterations in colorectal cancer through transcriptional subtype-based network analysis
High-throughput genomic studies have identified thousands of genetic alterations in colorectal cancer (CRC). Distinguishing driver from passenger mutations is critical for developing rational therapeutic strategies. Because only a few transcriptional subtypes exist in previously studied tumor types,...
ORGANISM(S): Mus musculus 
2013-12-22 | E-GEOD-38831 | biostudies-arrayexpress
TranscriptomicsGenetic reconstruction of a functional transcriptional regulatory network
Although global analyses of transcription factor binding provide one view of potential transcriptional regulatory networks, regulation also occurs at levels distinct from transcription factor binding. Here, we use a genetic approach to identify targets of transcription factors in yeast and reconstru...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-02 | E-GEOD-4654 | biostudies-arrayexpress
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