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MetabolomicsEpigenetic coordination of transcriptional and translational programs in hypoxia

Adaptation to cellular stresses entails an incompletely understood coordination of transcriptional and post-transcriptional gene regulation. Here, we quantified hypoxia-dependent transcriptomes, epigenomes and translatomes in T47D breast cancer cells and H9 human embryonic stem cells. This reveal...

2025-06-09 | MTBLS12086 | MetaboLights
MetabolomicsMetabolic and transcriptional response of Arabidopsis thaliana wildtype and mutants to Phytophtora infestans
The oomycete P. infestans is the causal agent of late blight, the most devastating potato disease. In contrast to potato, A. thaliana is able to successfully prevent colonization of the pathogen due to a multi-layered nonhost resistance. Several mutants have been isolated which are impaired in penet...
2025-07-04 | MTBLS18 | MetaboLights
TranscriptomicsTranscriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA-sequencing
Here, we apply differential transcriptome analysis on microscopically isolated cell populations, to define five transcriptional programs that represent each transient embryonic zone and the progression between these zones. The five transcriptional programs contain largely uncharacterized genes in ad...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-30765 | biostudies-arrayexpress
TranscriptomicsMaternal diabetes alters transcriptional programs in the developing embryo.
Exposure to maternal diabetes during pregnancy alters transcriptional profiles in the developing embryo. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developme...
ORGANISM(S): Mus musculus 
2012-09-25 | E-GEOD-41095 | biostudies-arrayexpress
TranscriptomicsGene expression programs in PBMCs elicited by 6 major mediators of the immune response.
Abstract: Background Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the product of direct and indirect effects, homotypic and heterotypic cell interactions. Dissecting the global...
ORGANISM(S): Homo sapiens 
2010-03-21 | E-GEOD-17762 | biostudies-arrayexpress
GenomicsControl of VEGF-A trancriptional programs by pausing and genomic compartmentalization
Vascular endothelial growth factor A (VEGF-A) is a master regulator of vascular development and function. Consequently, VEGF-A regulated gene expression programs have been under heavy research. In this study we study the transcriptional regulation of VEGF-A-responsive genes in primary aortic endothe...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-52642 | biostudies-arrayexpress
ProteomicsDLG2 knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognition
A complex train of events unfolds during brain development, guided by activation/repression of gene expression programs. It remains unclear how this process is disrupted in disease. Here we integrate human genetics with transcriptomic data from differentiation of human embryonic stem cells into cort...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD029526 | Pride
Human Dlg2 Neurons Lc-ms/ms 
ProteomicsPhosphatidylinositol-3-kinase p110 delta differentially restrains and directs naïve versus effector CD8+ T cell transcriptional programs Phosphatidylinositol-3-kinase p110 delta differentially restrains and directs naïve versus effector CD8+ T cell transcriptional programs
Phosphatidylinositol-3-kinase p110 delta (PI3Kp110δ) is pivotal for CD8+ T cell immune responses. To inform how PI3Kp110δ regulates CD8+ T cells, the current study focuses on PI3Kp110δ controlled transcriptional programs and reveals how PI3Kp110δ selectively induces and represses expression of key g...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-14 | PXD025046 | Pride
Pi3kp110δ T cell Tcr activation 
MetabolomicsMulti-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L.) Exposed to Water Deficit (Carotenoids; UPLC-DAD assay)

Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids...

2021-08-16 | MTBLS984 | MetaboLights
MetabolomicsMulti-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L.) Exposed to Water Deficit (Phenolics; UPLC-MS/MS assay)

Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids...

2019-04-07 | MTBLS898 | MetaboLights
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