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MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
TranscriptomicsIntrinsic Gene Expression Profiles of Gliomas are a Better Predictor of Survival than Histology
Histological classification of gliomas guides treatment decisions. Because of the high interobserver variability, we aimed to improve classification by performing gene expression profiling on a large cohort of glioma samples of all histological subtypes and grades. The seven identified intrinsic mol...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-16011 | biostudies-arrayexpress
GenomicsMixed Histology Lung Cancers Driven by Transcriptomic Features rather than Genomic Characteristics
Histology plays an essential role in therapeutic decision-making for lung cancer patients. However, the molecular determinants of lung cancer histology are largely unknown. We conducted whole-exome sequencing (WES) and microarray profiling on 19 micro-dissected tumor regions of different histologic ...
EGAS00001005140 | EGA
TranscriptomicsIntegration of Transcriptome, Gross Morphology and Histopathology in the Gill of Sea Farmed Atlantic Salmon (Salmo salar): Lessons from Multi-site Sampling
The experiment focused on the transcriptomic changes associated with gill inflammation in sea farmed Atlantic salmon (Salmo salar). To ensure the multifactorial aspect of gill inflammation, fish were sampled at three marine production sites (A on Isle of Mull, B in Shetland and C in Shetland) betwee...
ORGANISM(S): Salmo salar 
2020-06-01 | E-MTAB-8855 | biostudies-arrayexpress
UnknownHistology and Transcriptome Profiles of the Mammary Gland across Critical Windows of Development in Sprague Dawley Rats.
Not available
S-EPMC6103804 | biostudies-literature
TranscriptomicsTranscriptome analysis in human kidney to investigate whether fibrosis with inflammation at one year post transplant predicts transplant functional decline
We previously observed reduced graft survival for kidney transplants having interstitial fibrosis with subclinical inflammation, but not fibrosis alone, on 1-year protocol biopsy. The current study aimed to determine whether fibrosis with inflammation at 1 year is associated with renal functional de...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-22459 | biostudies-arrayexpress
GenomicsIntegrated genetic and epigenetic analysis defines novel molecular clusters in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. To unravel the genetic/epigenetic basis of RMS, we studied 60 RMS cases using whole exome/transcriptome sequencing, copy number (CN) profiling, and DNA methylome analysis. Based on DNA methylation patterns, RMS was clustered...
EGAS00001000884 | EGA
TranscriptomicsMalignant Fibrous Histiocytoma - Pleomorphic Sarcoma, NOS -Gene expression, Histology and clinical course -A pilot study
This study was performed to identify gene expression differences in not otherwise specified soft tissue sarcomas (NOS, malignant fibrous histiocytomas) and correlate them to histological findings and the clinical course. RNA was isolated and differential gene expression was analysed by the microarra...
ORGANISM(S): Homo sapiens 
2011-01-03 | E-GEOD-14325 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling by array of human angiosarcomas
Transcriptome signature of human angiosarcomas
ORGANISM(S): Homo sapiens 
2012-06-14 | E-MEXP-3271 | biostudies-arrayexpress
Transcriptomics10X Visium spatial RNA-seq from adult mouse brain sections paired to single-nucleus RNA-seq
We developed cell2location, a principled and versatile Bayesian model that is designed to resolve fine-grained cell types in spatial transcriptomic data and create comprehensive cellular maps of diverse tissues. To validate cell2location in real tissue, we applied the model to data from the mouse br...
ORGANISM(S): Mus musculus 
2021-11-12 | E-MTAB-11114 | biostudies-arrayexpress
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