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GenomicsExploring the Effects of Experimental Parameters and Data Modeling Approaches on In Vitro Transcriptomic Point-of-Departure Estimates
Exploring the Effects of Experimental Parameters and Data Modeling Approaches on In Vitro Transcriptomic Point-of-Departure Estimates
PRJNA1048916 | ENA
UnknownA Rat Liver Transcriptomic Point of Departure Predicts a Prospective Liver or Non-liver Apical Point of Departure.
Not available
S-EPMC7357187 | biostudies-literature
UnknownA microRNA or messenger RNA point of departure estimates an apical endpoint point of departure in a rat developmental toxicity model.
Not available
S-EPMC9324934 | biostudies-literature
GenomicsMultiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation
Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation
PRJNA854367 | ENA
TranscriptomicsComparing transcriptomic points of departure to apical effect concentrations for larval fathead minnow exposed to chemicals with four different modes of action
It is postulated that below a transcriptomic-based point of departure, adverse effects are unlikely to occur, thereby providing a chemical concentration to use in screening level hazard assessment. The present study extends previous work describing a high throughput fathead minnow assay that can pro...
ORGANISM(S): Pimephales promelas 
2024-10-18 | GSE252223 | GEO
TranscriptomicsEPA Transcriptomic Assessment Product (ETAP) for Perflurohexanesulfonamide
The EPA Transcriptomic Assessment Product (ETAP) utilizes a standardized short-term in vivo study design and data analysis procedures to develop transcriptomic-based reference values for data poor chemicals. This data set corresponds to a report following the ETAP standard methods to derive a transc...
ORGANISM(S): Rattus norvegicus 
2025-06-26 | GSE285856 | GEO
ProteomicsTranscriptomic points-of-departure (tPOD) derived from a 4-day rainbow trout embryo toxicity test were protective of apical effects for 17α-ethinylestradiol
There is an urgent demand for more efficient and ethical approaches in chemical risk assessment. Using 17α-ethinylestradiol (EE2) as a model compound, this study established a live-animal alternative embryo benchmark-dose (BMD) assay for rainbow trout (RBT; Oncorhynchus mykiss) to derive transcript...
ORGANISM(S): Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 
2021-08-17 | PXD025251 | Pride
Endocrine disruption Rainbow trout Benchmark dose Transcriptomic point-of-departure Ethinylestradiol Risk assessment 
TranscriptomicsEPA Transcriptomic Assessment Product (ETAP) for 7:3 Fluorotelomer alcohol
The EPA Transcriptomic Assessment Product (ETAP) utilizes a standardized short-term in vivo study design and data analysis procedures to develop transcriptomic-based reference values for data poor chemicals. This data set corresponds to a report following the ETAP standard methods to derive a transc...
ORGANISM(S): Rattus norvegicus 
2025-06-26 | GSE293924 | GEO
TranscriptomicsEPA Transcriptomic Assessment Product (ETAP) for 3:3 Fluorotelomer carboxylic acid
The EPA Transcriptomic Assessment Product (ETAP) utilizes a standardized short-term in vivo study design and data analysis procedures to develop transcriptomic-based reference values for data poor chemicals. This data set corresponds to a report following the ETAP standard methods to derive a transc...
ORGANISM(S): Rattus norvegicus 
2025-06-26 | GSE286156 | GEO
UnknownComparing Transcriptomic Points of Departure to Apical Effect Concentrations For Larval Fathead Minnow Exposed to Chemicals with Four Different Modes Of Action.
Not available
S-EPMC11305162 | biostudies-literature
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