Sort   by:  
 Page size 
TranscriptomicsExpression data from A549 cells after treatment with flagellin and transforming growth factor beta 1
We have examined the changes in gene expression aftert reatment of A549 cells, a cultured alveolar epithelial cells, with flagellin and transforming growth factor beta 1. In this dataset, we include the expression data obtained from A549 cells after treatment with purified flagellin or transforming...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-38309 | biostudies-arrayexpress
TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1.
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to a tumor promoter during neoplastic progression. Ionizing radiation (IR), both a carcinogen and a therapeutic agent, induces TGFbeta activation in vivo. We now show that I...
ORGANISM(S): Homo sapiens 
2008-11-08 | E-GEOD-8240 | biostudies-arrayexpress
ProteomicsProtein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)
his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western bl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080219 | MassIVE
TranscriptomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argu...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress
ProteomicsProtection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family
The 33 members of the transforming growth factor beta (TGF-β) family are fundamentally important for organismal development and homeostasis. Family members are synthesized and secreted as pro-complexes of non-covalently associated prodomains and growth factors (GF). Pro-complexes from a subset of fa...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD026841 | Pride
Transforming growth factor beta (tgf‐β) Bone morphogenetic protein (bmp) Electron microscopy (em) Hydrogen exchange mass spectrometry Activin 
MetabolomicsTGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights
TranscriptomicsThe transcriptional regulators TAZ and YAP direct Transforming Growth Factor-beta-induced tumorigenic phenotypes in breast cancer cells
Uncontrolled Transforming growth factor-beta (TGFβ) signaling promotes aggressive metastatic properties in late-stage breast cancers. However, how TGFβ-mediated cues are directed to induce late-stage tumorigenic events is poorly understood, particularly given that TGFβ has clear tumor suppressing ac...
ORGANISM(S): Homo sapiens 
2014-04-02 | E-GEOD-56445 | biostudies-arrayexpress
MetabolomicsInduction of resistance against Sclerotinia sclerotiorum in rapeseed by β-ocimene through enhanced production of coniferyl aldehyde

Rapeseed (Brassica napus) is an important oil resource, but its yield can be significantly compro-mised by Sclerotinia sclerotiorum (S. sclerotiorum) infection. Due to the lack of rapeseed strains that are highly or completely immune to S. sclerotiorum, enhancing rapeseed resistance through genet...

2025-07-04 | MTBLS12510 | MetaboLights
TranscriptomicsTransforming growth factor-B1 drives differentiation of the embryonic jejunum
Transcription profiling by microarray was performed to pinpoint the roles of transforming growth factor B1 (TGFB1) in embryonic differentiation of the small intestine. An organ culture system in which mouse jejunal rudiments were placed on semipermeable platforms and fed with chemically defined seru...
ORGANISM(S): Mus musculus 
2017-04-03 | E-MTAB-4509 | biostudies-arrayexpress
Sort   by:  
 Page size