Sort   by:  
 Page size 
ProteomicsProtein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)
his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western bl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080219 | MassIVE
TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1.
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to a tumor promoter during neoplastic progression. Ionizing radiation (IR), both a carcinogen and a therapeutic agent, induces TGFbeta activation in vivo. We now show that I...
ORGANISM(S): Homo sapiens 
2008-11-08 | E-GEOD-8240 | biostudies-arrayexpress
TranscriptomicsExpression data from A549 cells after treatment with flagellin and transforming growth factor beta 1
We have examined the changes in gene expression aftert reatment of A549 cells, a cultured alveolar epithelial cells, with flagellin and transforming growth factor beta 1. In this dataset, we include the expression data obtained from A549 cells after treatment with purified flagellin or transforming...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-38309 | biostudies-arrayexpress
MetabolomicsTGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights
TranscriptomicsLiver gene expression profiling of transforming growth factor beta receptor 2 heterozygous knockout (Tgfbr2+/-) mice
Transforming growth factor beta receptor 2 (Tgfbr2) was predicted as a causal gene for abdominal using a novel statistical method named LCMS (Schadt et al., 2005, Nature Genetics). In order to validate this prediction, we profiled the liver tissues of Tgfbr2 heterozygous knockout mice (Tgfbr2+/-) a...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11994 | biostudies-arrayexpress
TranscriptomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argu...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress
ProteomicsHuman EGFR AP-MS project
Mass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and interactome of wild type and endocytosis-defective EGFR variants before and after internalization in response to EGF or stress.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-23 | MSV000079525 | MassIVE
GenomicsHNF4A-binding sites in HepG2 hepatoblastoma cells treated with TGF-beta
Specific regulation of target genes by transforming growth factor-β (TGF-β) in a given cellular context is determined in part by transcription factors and cofactors that interact with the Smad complex. In the present study, we determined Smad2 and Smad3 (Smad2/3) binding regions in the promoters of ...
ORGANISM(S): Homo sapiens 
2011-06-08 | E-GEOD-28845 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor
Inhibition of the myostatin signaling pathway is emerging as a promising therapeutic means to treat muscle wasting disorders. Activin type IIB receptor is the putative myostatin receptor, and a soluble activin receptor (ActRIIB-Fc) has been demonstrated to potently inhibit a subset of TGF-β family m...
ORGANISM(S): Mus musculus 
2011-02-04 | E-GEOD-25306 | biostudies-arrayexpress
Sort   by:  
 Page size