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TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease [NimbleGen]
The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestatin...
ORGANISM(S): Rattus norvegicus 
2014-07-17 | E-GEOD-59277 | biostudies-arrayexpress
TranscriptomicsDioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations
Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote e...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59552 | biostudies-arrayexpress
TranscriptomicsHydrocarbons (Jet Fuel JP-8) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats wer...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59553 | biostudies-arrayexpress
TranscriptomicsPesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a M-bM-^@M-^\pesticide mixtureM-bM-^@M-^] (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerationa...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59554 | biostudies-arrayexpress
TranscriptomicsGerm cell epigenetic instability in the Mtrr mouse model of transgenerational epigenetic inheritance
Folate metabolism is important for the generation of methyl groups required for cellular methylation reactions. Mice with a hypomorphic mutation in the gene Mtrr have disrupted folate metabolism and show transgenerational inheritance of developmental abnormalities. We sought to explore if DNA methyl...
ORGANISM(S): Mus musculus 
2021-04-06 | E-MTAB-8533 | biostudies-arrayexpress
TranscriptomicsPlastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1M-bM-^@M-^SF3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived en...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59555 | biostudies-arrayexpress
TranscriptomicsGenetic stability and germ cell epigenetic instability in the Mtrr mouse model of transgenerational epigenetic inheritance.
Folate metabolism is important for DNA synthesis and repair through its role in the synthesis of the nucleotide thymidine. Mice with a hypomorphic mutation in the gene Mtrr have disrupted folate metabolism and show transgenerational inheritance of developmental abnormalities. We sought to explore if...
ORGANISM(S): Mus musculus 
2021-04-06 | E-MTAB-8513 | biostudies-arrayexpress
TranscriptomicsEnvironmentally induced epigenetic transgenerational inheritance of ovarian disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-07-17 | E-GEOD-59278 | biostudies-arrayexpress
GenomicsChromatin epimutations in transgenerational epigenetic inheritance
Chromatin epimutations in transgenerational epigenetic inheritance
PRJNA872365 | ENA
ProteomicsA nuclear pore-anchored condensate enables germ granule organisation and transgenerational epigenetic inheritance
Biomolecular condensates, such as stress and germ granules, often contain sub-compartments. For instance, the Caenorhabditis elegans germ granule, which localizes near the outer nuclear membrane of germ cell nuclei, is composed of at least four ordered compartments, each housing distinct sets of pro...
ORGANISM(S): Caenorhabditis elegans 
2025-02-09 | PXD056752 | Pride
Transgenerational epigenetic inheritance Ddx-19 Condensates C.elegans 
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