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MetabolomicsOperational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures (Cohort 2).
The mechanisms underlying operational tolerance after hematopoietic stem cell transplantation in humans are poorly understood. We studied two independent cohorts of patients who underwent allogeneic hematopoietic stem cell transplantation from human leukocyte antigen-identical siblings. Primary tole...
2021-12-22 | MTBLS221 | MetaboLights
MetabolomicsOperational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures (Cohort 1).
The mechanisms underlying operational tolerance after hematopoietic stem cell transplantation in humans are poorly understood. We studied two independent cohorts of patients who underwent allogeneic hematopoietic stem cell transplantation from human leukocyte antigen-identical siblings. Primary tole...
2021-12-22 | MTBLS220 | MetaboLights
MetabolomicsMitochondrial Transplantation Ameliorates Doxorubicin-Induced Cardiac Dysfunction via Activating Glutamine Metabolism
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
2025-03-13 | MTBLS7989 | MetaboLights
MetabolomicsLinking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in pediatric hematopoietic stem cell transplantation

BACKGROUND: Hematopoietic stem cell transplantation is a curative procedure for a variety of conditions. Despite major advances, a plethora of adverse clinical outcomes can develop post-transplantation including graft-versus-host disease and infections, which remain the major cau...

2022-05-11 | MTBLS4065 | MetaboLights
MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
MetabolomicsDonor Gut MicrobialDrives Fecal Microbiota Transplantation Efficacy in ulcerative colitis

Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic strategy for Inflammatory Bowel Disease (UC), though its clinical success appears contingent upon donor microbiota engraftment degree. While microbial colonization dynamics remain poorly understood, our study identifies...

2026-01-11 | MTBLS12531 | MetaboLights
MetabolomicsEffect of transplantation of irradiated mouse feces on blood short chain fatty acids in recipient mice
In order to study the effect of transplantation of irradiated mouse feces on the short chain fatty acids in the blood of recipient mice, we used mobile phones to transplant the feces of donor mice from 1W to 4W after irradiation. After 2W of antibiotic intervention, fecal bacteria were transplanted ...
2026-09-28 | MTBLS15752 | MetaboLights
MetabolomicsGut microbiome and metabolome dynamics as predictors of clinical outcomes in hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) induces significant alterations in the gut microbiome and metabolome, which influence transplant-related complications and surviv-al. This study longitudinally analyzed gut microbiota and metabolites at pre- (T1), peri- (T2), and post-transplant (T3) st...
2025-07-30 | MTBLS12365 | MetaboLights
MetabolomicsMacrosteatosis Cause Graft Failure Via Proliferative Arrest in Rats after Liver Transplantation
We created a rat model with macrosteatosis (MaS) liver via methionine-cholinedeficient food (MCD) diet and transplanted the MaS liver into normal rats, then the rats without any MaS will be set as control. In the whole process of surgeries, we procured the liver tissue samples in different time poin...
2023-11-20 | MTBLS4163 | MetaboLights
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