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ProteomicsMaternally inherited piRNAs silence transposons during Drosophila embryogenesis
The piRNA pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. piRNAs are maternally deposited and required for proper transposon silencing in adult offspring. However, a long-standing question in the field is the precise function of matern...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-07-26 | PXD022409 | Pride
Drosophila Embryogenesis Pirna Tmt-ms 
TranscriptomicsExpression of genes and transposons in mop1 mutants and non-mutants
Transposable elements (TEs) comprise a substantial portion of many eukaryotic genomes and are typically transcriptionally silenced. RNA–dependent RNA polymerase 2 (RDR2) is a component of the RNA–directed DNA methylation (RdDM) silencing pathway. In maize, loss of mediator of paramutation1 (mop1) en...
ORGANISM(S): Zea mays 
2009-11-20 | E-GEOD-16789 | biostudies-arrayexpress
GenomicsMultiple roles for Piwi in silencing Drosophila transposons
Silencing of transposons in the Drosophila ovary relies on three Piwi-family proteins, Piwi, Aubergine (Aub), and Ago3, acting in concert with their small RNA guides, the piRNAs. Aub and Ago3 are found in the germ cell cytoplasm, where they function in the ping-pong cycle to consume transposon mRNA...
ORGANISM(S): Drosophila melanogaster 
2013-02-09 | E-GEOD-43360 | biostudies-arrayexpress
TranscriptomicsLarge numbers of putative miRNAs originate from DNA transposons and are coincident with a large species radiation in bats.
Vesper bats (family Vespertilionidae) experienced a rapid adaptive radiation beginning around 36 mya that resulted in the second most species rich mammalian family. Coincident with that radiation was an initial burst of DNA transposon activity that has continued into the present. Deep sequencing o...
ORGANISM(S): Equus caballus 
2014-05-19 | E-GEOD-47593 | biostudies-arrayexpress
TranscriptomicsEndogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA as a defense against viral infection. Here, we identify 21-nt long, endogenous siRNAs (endo-siRNAs) corresponding to transposons and heterochromatic...
ORGANISM(S): Drosophila melanogaster 
2008-04-10 | E-GEOD-11019 | biostudies-arrayexpress
Genomicsp53 directly represses human LINE1 transposons
p53 directly represses human LINE1 transposons
PRJNA667740 | ENA
TranscriptomicsA piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
We examined the construction of the piRNA system in the restricted developmental window in which methylation patterns are set during mammalian embryogenesis. We find robust expression of two Piwi family proteins, MIWI2 and MILI. Their associated piRNA profiles reveal differences from Drosophila wher...
ORGANISM(S): Mus musculus 
2008-10-01 | E-GEOD-12757 | biostudies-arrayexpress
TranscriptomicsSmall RNA-based silencing strategies for transposons in the process of invading Drosophila species
We investigated a pool of small RNAs derived from transposon Penelope to probe the evolution of small RNA pathways in response to the transposon challenge in natural (D. virilis) and experimentally induced (D. melanogaster) colonization processes. In both species, Penelope was predominantly targeted...
ORGANISM(S): Drosophila melanogaster 
2010-07-18 | E-GEOD-22067 | biostudies-arrayexpress
GenomicsSINE transposons
SINE transposons in multiple lepidopteran insects Raw sequence reads
PRJNA665855 | ENA
TranscriptomicsLoss of the DNA methyltransferase MET1 induces H3K9 hypermethylation at PcG target genes in Arabidopsis, and relocation of H3K27 trimethylation to transposons [RNA-seq]
Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein coding genes, whil...
ORGANISM(S): Arabidopsis thaliana 
2016-06-22 | E-GEOD-83607 | biostudies-arrayexpress
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