Sort   by:  
 Page size 
ProteomicsNucleophagy removes cytotoxic trapped PARP1
Poly (ADP-ribose) polymerase inhibitors (PARPi) induce cytotoxicity in homologous recombination repair (HRR)-deficient cancers by causing PARP1 to become trapped on chromatin, resulting in irreparable replication-associated DNA damage. Cancer cells commonly develop resistance to PARPi, with a recent...
ORGANISM(S): Homo sapiens (Human) 
2026-04-15 | PXD071389 | Pride
Hdx-ms 
GenomicsSelective nucleophagy removes cytotoxic trapped PARP1
Selective nucleophagy removes cytotoxic trapped PARP1
PRJNA1162042 | ENA
ProteomicsImmunoprecipitated PARP1 interactome
Poly-(ADP-ribose) polymerase inhibitors (PARPi) elicit anti-tumour activity in homologous recombination defective cancers by promoting cytotoxic, chromatin-bound, “trapped” PARP1 DNA lesions. How cells process trapped PARP1 remains unclear. By exploiting wild-type or trapping-resistant PARP1 transge...
ORGANISM(S): Homo sapiens (Human) 
2021-10-05 | PXD024337 | Pride
Trapped parp1 Breast cancer Parp1 Rime Vcp Apex2 proximity labelling 
TranscriptomicsSelective nucleophagy removes cytotoxic trapped PARP1
Poly (ADP-ribose) polymerase inhibitors (PARPi) induce cytotoxicity in homologous recombination deficient cancers by causing PARP1 to become trapped on chromatin, resulting in irreparable replication-associated DNA damage. Cancer cells commonly develop resistance to PARPi, with a recently proposed m...
ORGANISM(S): Homo sapiens 
2026-03-23 | GSE277366 | GEO
UnknownThe ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Not available
S-EPMC8760077 | biostudies-literature
UnknownReplication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.
Not available
S-EPMC8501961 | biostudies-literature
UnknownUSP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity.
Not available
S-EPMC11559621 | biostudies-literature
UnknownXRCC1 prevents toxic PARP1 trapping during DNA base excision repair.
Not available
S-EPMC8294329 | biostudies-literature
UnknownKAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer.
Not available
S-EPMC11425913 | biostudies-literature
UnknownFANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells.
Not available
S-EPMC10960859 | biostudies-literature
Sort   by:  
 Page size