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TranscriptomicsSNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH
Many studies estimate that chromosomal mosaicism within the cleavage stage human embryo is high. However, comparison of two unique methods of aneuploidy screening of blastomeres within the same embryo has not been conducted and may indicate whether mosaicism is overestimated due to technical incons...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-20975 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of undifferentiated and differentiated mouse embryonic stem cells in the presence or absence of neurogenin 3 (Ngn3) expression to better characterize the molecular events regulated by Ngn3 during development.
Expression of the proendocrine gene neurogenin 3 (Ngn3) is required for the development of pancreatic islets. In order to better characterize the molecular events regulated by Ngn3 during development, we have determined the expression profile of differentiating murine embryonic stem cells (mESCs) u...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3653 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of inducible Ngn3 mouse embryonic stem cells
16 embryonic stem cell (ESC) samples (8 groups in duplicate) were processed for microarray analysis using the Affymetrix Mouse Genome 430 2.0 GeneChip. The samples included the parental Ainv15 ESC line (1) undifferentiated (Ainv15 ESC), (2) differentiated for 3 days as embryoid bodies (Ainv15 EB3) o...
ORGANISM(S): Mus musculus 
2007-06-29 | E-CBIL-29 | biostudies-arrayexpress
TranscriptomicsSNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts
Preimplantation genetic diagnosis (PGD) of aneuploidy by fluorescence in situ hybridisation (FISH) has not delivered the expected clinical benefit. Many previous re-analysis studies of embryos deemed aneuploid by FISH on day 3 have found a high degree of chromosomal normalcy at the blastocyst stage...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-18932 | biostudies-arrayexpress
TranscriptomicsValidation of rapid embryo tracking using cell-free fetal DNA enriched from maternal circulation at 9 weeks gestation
Embryo DNA fingerprinting represents an important tool for tracking embryo-specific outcomes after multiple embryo transfer during IVF. The situation in which 2 embryos are transferred and only one implants represents a unique opportunity for the most well-controlled comparison of competent and inc...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-26404 | biostudies-arrayexpress
TranscriptomicsHuman embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest
Nuclear abnormalities are commonly found in human IVF embryos and are associated with DNA damage, aneuploidy, and decreased developmental potential. Immunohistochemical, microscopic, and cytogenetic analysis of human IVF embryos at different developmental stages and morphologic grades.
ORGANISM(S): Homo sapiens 
2015-09-11 | E-GEOD-72150 | biostudies-arrayexpress
UnknownIdentifying parental and cell-division origins of aneuploidy in the human blastocyst.
Not available
S-EPMC10119141 | biostudies-literature
TranscriptomicsSingle Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses
Methods of comprehensive microarray based analyses of single cell DNA are rapidly emerging. Whole genome amplification (WGA) remains a critical component for these methods to be successful. A number of commercially available WGA kits have been independently utilized in previous single cell microar...
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-24690 | biostudies-arrayexpress
TranscriptomicsPossible Genetic Basis for Failure of a Robotic-Assisted Laparoscopic Sacrocolpopexy
Sacrocolpopexy has been dubbed the “gold standard” repair for apical pelvic organ prolapse (POP). This study sought to determine a genetic cause for sacrocolpopexy failure by comparing genotypes from 10 women who suffered from early POP reoccurance after sacrocolpopexy surgery, versus 40 random...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-63236 | biostudies-arrayexpress
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