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TranscriptomicsTranscription profiling of trigeminal ganglia of Brn3a knockout and wild type mice to determine the regulatory targets of transcription factor Brn3a.
Mice lacking the POU-domain transcription factor Brn3a exhibit marked defects in sensory axon growth and abnormal sensory apoptosis. We have determined the regulatory targets of Brn3a in the developing trigeminal ganglion using microarray analysis of Brn3a mutant mice. These results show that Brn3 m...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3895 | biostudies-arrayexpress
TranscriptomicsThe star-nosed mole reveals clues to the molecular basis of mammalian touch.
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demo...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-47480 | biostudies-arrayexpress
TranscriptomicsRNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model
The epigenetic roles in trigeminal neuralgia (TN) still remain unclear. H3K9ac alteration in neuralgia is obscure and controversy. In this study, we established TN rat model via chronic compression, and further treated with 100 mg/kg/d carbamazepine (CBZ). RNA-seq were conducted to investigate the t...
ORGANISM(S): Rattus norvegicus 
2021-08-02 | E-MTAB-10792 | biostudies-arrayexpress
TranscriptomicsChIP-seq to investigate H3K9ac regulation by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model
The epigenetic roles in trigeminal neuralgia (TN) still remain unclear. H3K9ac alteration in neuralgia is obscure and controversy. In this study, we established TN rat model via chronic compression, and further treated with 100 mg/kg/d carbamazepine (CBZ). ChIP-seq were conducted to investigate the ...
ORGANISM(S): Rattus norvegicus 
2021-08-02 | E-MTAB-10793 | biostudies-arrayexpress
TranscriptomicsTrigeminal Ganglion Transcriptome Analysis in Rat Models of Medication Overuse Headache Reveals Coherent and Widespread Induction of Pronociceptive Gene Expression Patterns
Transcriptome analysis on samples of trigeminal ganglia harvested in rats treated with triptans or indomethacin, experimental model of medication for headache overuse
ORGANISM(S): Rattus norvegicus 
2017-12-31 | E-MTAB-5864 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of trigeminal ganglia from C57BL/6 (wild-type) and Rag1KO mice with dry eye (extraorbital lacrimal gland excision model) versus sham-operated controls
Comparison of the effect of ocular surface desiccation and the lack of adaptive immunity (T and B cells) on gene expression in the trigeminal ganglia. Eight-week-old female mice of both strains were either operated on day 1 (either bilateral extraorbital lacrimal gland excision or sham surgery) and ...
ORGANISM(S): Mus musculus 
2024-04-01 | E-MTAB-13945 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of trigeminal ganglia from C57BL/6 (wild-type) and Trpv1KO mice with uni- and bilateral dry eye (uni- and bilateral extraorbital lacrimal gland excision model) versus sham-operated controls
The uni- and bilateral excision models allow comparison of the combined effects of ocular desiccation and neuroinflammation on trigeminal gene expression vs the isolated effects of neuroinflammation propagated from the other side. Also, the transient receptor potential vanilloid 1 (Trpv1)-deficient ...
ORGANISM(S): Mus musculus 
2025-07-01 | E-MTAB-15193 | biostudies-arrayexpress
ProteomicsPhosphoproteomics Uncovers a Neuroimmune Perspective on Trigeminal Neuralgia: Sexually Dimorphic Regulatory Networks Linking Calcium Channels to the Complement Cascade
Background: Trigeminal neuralgia (TN) is a debilitating neuropathic pain disorder with a higher prevalence in females, yet its pathogenic mechanisms and underlying sexual dimorphism remain incompletely understood. Phosphorylation modifications are critical regulators of pain signaling, but comprehen...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-26 | PXD066745 | Pride
Rigeminal neuralgia  phosphoproteomics  neuroimmune crosstalk  complement c1q  mapkapk2–hspb1 axis 
TranscriptomicsTranscription profiling of mouse spinal and trigeminal sensory ganglia of Brn3a knockout and wild type mice reveals conserved and distinct regulatory targets of Brn3a at different levels of the sensory axis
General somatic sensation is conveyed to the central nervous system at cranial levels by the trigeminal ganglion (TG), and at spinal levels by the dorsal root ganglia (DRG). Although these ganglia have similar functions, they have distinct embryological origins, in that both contain neurons origina...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5658 | biostudies-arrayexpress
TranscriptomicsAnti-CGRP Monoclonal Antibodies Counteract Interoceptive Awareness of Malaise
Study of the expression profiles of brain regions (amygdala, hippocampus and cerebral cortex) and trigeminal ganglia collected from rats treated with fremanezumab, an anti-calcitonin gene related peptide (CGRP) mAb, used for the prevention of migraine.
ORGANISM(S): Rattus norvegicus 
2024-05-30 | E-MTAB-13507 | biostudies-arrayexpress
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