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TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
TranscriptomicsSelective ribosome profiling reveals the co-translational chaperone action of trigger factor in vivo
As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting and folding factors. Here we present a selective ribosome profiling strategy that enables global monitoring of when these factors engage polypeptides in the complex cellular environment. Studies of the Esch...
ORGANISM(S): Escherichia coli 
2011-12-09 | E-GEOD-33671 | biostudies-arrayexpress
UnknownThe dynamics of capillary flow in an open-channel system featuring trigger valves.
Not available
S-EPMC11686082 | biostudies-literature
UnknownThe dynamics of capillary flow in an open-channel system featuring trigger valves.
Not available
S-EPMC11429806 | biostudies-literature
ProteomicsAffinity Purification Trigger with mTPP
We have applied a BASIL-like approach to increase the signal of low abundance peptides to the study of protein complexes. To accomplish this, we incorporated an affinity purified cleavage and polyadenylation factor (CPF) complex as a “trigger” into our mTPP workflow at a trigger sample to lowest hea...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD020689 | Pride
Ap-ms Tpp Lc-ms/ms 
ProteomicsPIP2 promotes MLKL-derived pathogenic process through enhancing its channel activity
PIP2 enhances MLKL channel activity in a direct interaction manner and this gain of function promotes both necroptosis and inflammation. Previous studies have reported that phospholipids assisted MLKL recruitment and translocation which facilitates its mediated function like liposome leaking. Here, ...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-05 | PXD030814 | Pride
Bv2 lps mlkl lc/msms pip2 
UnknownAn intersubunit trigger of channel gating in the muscle nicotinic receptor.
Not available
S-EPMC6672532 | biostudies-literature
ProteomicsIon channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
Targeted protein degradation or downregulation (TPD/TPDR) mediated by induced recruitment of an endogenous E3 ubiquitin ligase to a substrate is a disruptive paradigm for developing therapeutics. However, <2% of ~600 E3 ligases have been exploited for this modality, and efficacy for multi-subunit me...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD069051 | Pride
Hek293 cells Nedd4-2 Divalent nanobody Ion channels 
UnknownThe Venus flytrap trigger hair-specific potassium channel KDM1 can reestablish the K+ gradient required for hapto-electric signaling.
Not available
S-EPMC7725304 | biostudies-literature
TranscriptomicsLarval application of sodium channel homologous dsRNA restores pyrethroid insecticide susceptibility in a resistant adult mosquito population
Mosquitoes host and pass on to humans a variety of disease-causing pathogens such as infectious viruses and other parasitic microorganisms. The emergence and spread of insecticide resistance is threatening the effectiveness of current control measures for common mosquito vector borne diseases, such ...
ORGANISM(S): Aedes aegypti 
2016-07-06 | E-GEOD-84030 | biostudies-arrayexpress
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