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UnknownCranial radiation for pediatric T-lineage acute lymphoblastic leukemia: a systematic review and meta-analysis.
There are heterogeneous approaches to cranial radiation therapy (CRT) for T-lineage acute lymphoblastic leukemia (T-ALL). We performed a systematic review of studies that specified a radiation strategy and reported survival for pediatric T-ALL. Our analysis included 62 publications reporting 78 trea...
S-EPMC4167220 | biostudies-literature
UnknownParaoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.

Purpose

Paraoxonase 1 (PON1) polymorphisms have been implicated as risk factors for coronary artery disease, but the results of genetic association studies on the related phenotype of ischemic stroke are inconclusive. We performed a meta-analysis of published studies investigating the associ...
S-EPMC3081717 | biostudies-literature
UnknownCost-effectiveness of Testing and Treatment for Latent Tuberculosis Infection in Residents Born Outside the United States With and Without Medical Comorbidities in a Simulation Model.

Importance

Testing for and treating latent tuberculosis infection (LTBI) is among the main strategies to achieve TB elimination in the United States. The best approach to testing among non-US born residents, particularly those with comorbid conditions, is uncertain.

Objective

To estim...
S-EPMC5808933 | biostudies-literature
UnknownPotential for Point-of-Care Tests to Reduce Chlamydia-associated Burden in the United States: A Mathematical Modeling Analysis.

Background

Point-of-care testing (POCT) assays for chlamydia are being developed. Their potential impact on the burden of chlamydial infection in the United States, in light of suboptimal screening coverage, remains unclear.

Methods

Using a transmission model calibrated to data in the...
S-EPMC7048627 | biostudies-literature
UnknownStrategies and Outcomes of Age-Friendly Health System Implementation in Outpatient Settings: A Systematic Review.
The Age-Friendly Health System (AFHS) movement has spread widely in recent years, with nearly 5000 healthcare organizations across the country recognized as Age-Friendly. Despite this broad recognition, there is little focus on how AFHS are implemented and the impact of implementation. The objective...
S-EPMC11826848 | biostudies-literature
UnknownEstimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors.

Background

Disparities in the health and economic burden of gonorrhoea have not been systematically quantified. We estimated population-level health losses and costs associated with gonococcal infection and sequelae in the United States.

Methods

We used probability-tree models ...
S-EPMC9904145 | biostudies-literature
UnknownComparative effectiveness of venous thromboembolism prophylaxis options for the patient undergoing total hip and knee replacement: a network meta-analysis.
Essentials Despite trial data, guidelines have not endorsed direct oral Xa inhibitors above other options. We provide profiles of venous thromboembolism and hemorrhage risk for 12 options. Direct oral Xa inhibitors had a favorable profile compared with low-molecular-weight heparin. Other options did...
S-EPMC5305416 | biostudies-literature
UnknownQuality improvement strategies for diabetes care: Effects on outcomes for adults living with diabetes.
Not available
S-EPMC10233616 | biostudies-literature
UnknownLarge-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.

Context

Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population.

Objective

To generate large-scale evidenc...
S-EPMC3282142 | biostudies-literature
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