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ProteomicsMesoscale regulation of microtubule-organising centres by the E3 ligase TRIM37
Centrosomes ensure accurate chromosome segregation during cell division. Although the regulation of centrosome number is well-established, less is known about the suppression of non-centrosomal Microtubule-Organising Centres (ncMTOCs). The E3 ligase TRIM37, implicated in Mulibrey nanism and 17q23-am...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD061083 | Pride
E3 ubiquitin ligases Centrosomes and mtocs 17q23-amplified cancers Trim37 Mulibrey nanism disorder Trim proteins Mesoscale protein assembly 
GenomicsTRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration
TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration
PRJNA1222434 | ENA
TranscriptomicsTRIM37 is a novel H2A ubiquitin ligase and a Breast Cancer Oncogene
The TRIM37 gene is mutatedin Mulbery nanism, a rare autosomal recessive disorder, and is in the 17q23 chromosomal region that is amplified in up to ~40% of breast cancers. Trim37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases, but the protein substrate(s) of Trim37 is unknown. Mo...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-48196 | biostudies-arrayexpress
GenomicsThe ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
PRJNA623614 | ENA
GenomicsTonEBP increases TRIM37
TonEBP increases TRIM37
PRJNA896497 | ENA
GenomicsTRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration [ATAC-seq]
TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration [ATAC-seq]
PRJNA1222435 | ENA
GenomicsTRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration
During embryo development, germ cells segregate from soma to ensure the genome transmission of a species. Although the repression of somatic programs in germline specification is well studied, the molecular mechanisms that protect primordial germ cell (PGC) fate thereafter remain poorly understood. ...
ORGANISM(S): Mus musculus 
2026-06-26 | GSE289334 | GEO
GenomicsTRIM37 is a novel H2A ubiquitin ligase and a Breast Cancer Oncogene
The TRIM37 gene is mutatedin Mulbery nanism, a rare autosomal recessive disorder, and is in the 17q23 chromosomal region that is amplified in up to ~40% of breast cancers. Trim37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases, but the protein substrate(s) of Trim37 is unknown. Mon...
ORGANISM(S): Homo sapiens 
2014-10-06 | GSE48196 | GEO
UnknownTRIM37 controls cancer-specific vulnerability to PLK4 inhibition.
Not available
S-EPMC7501188 | biostudies-literature
GenomicsTRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration [bulkRNA-seq, scRNA-seq]
TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration [bulkRNA-seq, scRNA-seq]
PRJNA1222436 | ENA
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