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TranscriptomicsCXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by infiltration of the bone marrow and other sites with transformed T cell progenitors. The role of tissue microenvironments in the pathogenesis of T-ALL or any other type of acute leukemia is little ...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-60367 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling in human T-ALL
Genome-wide mapping and characterization of novel Notch-regulated long non-coding RNAs in acute leukemia Total RNA was extracted from samples using the RNeasy Plus mini kit (Life Technologies, Carlsbad, CA). Samples were then subject to PolyA selection (Figures 1E, 5F and 5G only) using oligo-dT be...
ORGANISM(S): Homo sapiens 
2014-08-18 | E-GEOD-57982 | biostudies-arrayexpress
TranscriptomicsExpression data from vehicle or PD-0332991 treated human T-ALL lines
Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-40635 | biostudies-arrayexpress
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT and LSK N1-C+
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27799 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT and LSK NcstnKO
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27794 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT, GMP WT and GMP NcstnKO
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27811 | biostudies-arrayexpress
UnknownGenetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
Not available
S-EPMC3274628 | biostudies-literature
TranscriptomicsNotch1-driven transcriptional changes in a mouse model of T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we used a mouse model of T-ALL through the overexpression of the intarcellular transcriptionally active part of Notch1 (N1-IC). This model fait...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-34554 | biostudies-arrayexpress
UnknownUnderstanding metastasis mixed-treatment responses through genomic analyses.
Not available
S-EPMC11782668 | biostudies-literature
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