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no omics definedTranscription profiling of human mesenchymal stem cells transfected with adenoviruses carrying the SOX trio or LacZ control to identify target molecules
The aim of the experiment is to identify target molecules of the SOX trio (SOX9, SOX5 and SOX6). hMSC were transfected with the adenoviruses carrying the SOX trio or the LacZ-control, and total RNA was isolated after 2 weeks of culture.
ORGANISM(S): Homo sapiens 
2007-04-01 | E-MEXP-960 | biostudies-arrayexpress
ProteomicsAutoinhibition of Trio guanine nucleotide exchange factor activity for Rac1 by its spectrin repeats is disrupted by neurodevelopmental disorder-related genetic variants
Crosslinking MS of SR6-GEF1 construct of Human Trio. BS3 crosslinking of wild-type and three point mutants implicated in neurodevelopmental disorders (E883D, R1078Q, D1368V). Data acquired using FAIMS ion mobility source with each sample acquired at 4 different CVs (-40, -50, -60, -70V).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-08 | MSV000089621 | MassIVE
ProteomicsAutoinhibition of Trio guanine nucleotide exchange factor activity for Rac1 by its spectrin repeats is disrupted by neurodevelopmental disorder-related genetic variants.
Function-damaging variants in the TRIO gene are enriched in individuals with neurodevelopmental disorders (NDDs). TRIO encodes a cytoskeletal regulatory protein with three catalytic domains – two guanine exchange factor (GEF) domains, GEF1 and GEF2, and a kinase domain, as well as several accessory ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-13 | PXD034393 | Pride
Limited proteolysis Neurodevelopment disorders Trio gene Crosslinking 
ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
TranscriptomicsmRNA-Seq for homoeologous gene expression analysis in hexaploid bread wheat
Bread wheat (Triticum aestivum) has a large, complex and hexaploid genome consisting of A, B and D homoeologous chromosome sets. Therefore each wheat gene potentially exists as a trio of A, B and D homoeoalleles, each of which may contribute differentially to wheat phenotypes. We describe a novel ap...
ORGANISM(S): Triticum aestivum 
2014-04-22 | E-MTAB-4223 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for Pediatric malignant glioma samples
Data includes all available Affymetrix SNP data from a cohort of Pediatric malignant glioma samples, isolated from Formalin-fixed Paraffin embedded tissue. No clinical data is available. Copy number analysis of Affymetrix 250K Sty SNP arrays was performed for 28 pediatric malignant gliomas. The VN a...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-25589 | biostudies-arrayexpress
TranscriptomicsRecurrent TRIO fusion in non-translocation-related sarcomas
We used NGS on a cohort of complex genetics sarcomas to study their transcriptomes (RNA-seq technology), looking for recurrent and specific gene fusions. We identified multiple TRIO fusions with different partners in our cohort. No TRIO fusions were reported in negative-control cells (normal tissues...
ORGANISM(S): Homo sapiens 
2017-03-07 | GSE75885 | GEO
UnknownDentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells.
Not available
S-EPMC11748712 | biostudies-literature
UnknownAssociation testing to detect gene-gene interactions on sex chromosomes in trio data.
Not available
S-EPMC3826485 | biostudies-literature
TranscriptomicsGain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [camb1Mb data]
For many oncogenes, increased expression resulting from copy number gain confers a selective advantage to cells that consequently make up the tumour bulk. To identify oncogenes of potential biological significance in cervical squamous cell carcinoma (SCC), 36 primary samples and ten cell lines were ...
ORGANISM(S): Homo sapiens 
2011-02-16 | E-GEOD-27332 | biostudies-arrayexpress
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