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MetabolomicsCharacterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights
MetabolomicsVesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer

Selective autophagy of mitochondria is known to promote survival and progression of cancer cells in various malignancies, including triple-negative breast cancer (TNBC). Here, we investigate the essential metabolic adaptations that support mitochondrial quality control in cancer cells with the ai...

2025-09-30 | MTBLS13037 | MetaboLights
MetabolomicsTargeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer

Bone metastasis is a lethal consequence of breast cancer. AT-rich interaction domain 1A gene (ARID1A), a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, regulates immunosuppressive tumor microenvironment. ARID1A deficient triple negative breast cancer promotes bone metastasis.To ...

2026-03-24 | MTBLS12768 | MetaboLights
MetabolomicsMetabolomics Analysis of Triple Negative Breast Cancer (BCa) Cell Lines
Not available
ORGANISM(S): Homo sapiens 
ST000442 | MetabolomicsWorkbench
MetabolomicsMulti-omic Analysis of ClpP Activation in Triple-Negative Breast Cancer Cells
Not available
ORGANISM(S): Homo sapiens 
ST002408 | MetabolomicsWorkbench
TranscriptomicsTranscriptomes of triple negative breast cancer enriched breast cancer cohort
Breast cancers enriched for the triple negative breast cancer phenotype with extensive clinico-pathological features were profiled to establish their comprehensive transcriptional profiles
ORGANISM(S): Homo sapiens 
2016-11-21 | E-MTAB-5270 | biostudies-arrayexpress
OtherThe proteomic landscape of triple-negative breast cancer
Data from ProteomicsDB, ID: PRDB004167. Experiment: MCF10A_Trypsin_rep1, file: folder summary. Published as part of Cell Rep. 2015 Apr 15. pii: S2211-1247(15)00341-1 . From the Abstract: {{i}} Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical outcomes and a sho...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320015247 | GPMDB
TranscriptomicsMolecular Characterization of Basal-like and Non-Basal-like Triple-Negative Breast Cancers
Triple-negative (TN) and Basal-like (BL) breast cancer definitions have been used interchangeably to identify breast cancers that lack expression of the hormonal receptors (HR) and overexpression and/or amplification of HER2. However, both classifications when compared to each other, show substantia...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-41119 | biostudies-arrayexpress
TranscriptomicsHMGA1: A master regulator of tumor progression in triple-negative breast cancer cells
Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process are poorly understood. Here, we show for the first time that the high mobility group A1 (HMGA1) gene drives metastatic progression in triple ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-45483 | biostudies-arrayexpress
MetabolomicsApplication of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Not available
ORGANISM(S): Homo sapiens 
ST002235 | MetabolomicsWorkbench
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