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GenomicsTriplet nucleotide repeat-based siRNAs are highly toxic to cancer cells
Triplet nucleotide repeat-based siRNAs are highly toxic to cancer cells
PRJNA413038 | ENA
TranscriptomicsTranscription profiling of human lymphoblast cells from a Freidriechs Ataxia patient incubated with pyrrole-imidazole polyamides targeted to the GAA triplet repeat in the intron 1 reveals polyamides alleviate transcription inhibition associated with long repeat srepeats in Friedreicha??s ataxia
Lymphoblast cells from a patient with Freidriech's Ataxia were incubated with pyrrole-imidazole polyamides targeted to the GAA triplet repeat in the intron 1. The polyamides were shown in cell culture to increase levels of endogenous frataxin mRNA. A normal sibling derived lymphoblast cell line wa...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5040 | biostudies-arrayexpress
TranscriptomicsFriedreichâ??s Ataxia Induced Pluripotent Stem Cells Recapitulate GAAâ?¢TTC Triplet-Repeat Instability
The inherited neurodegenerative disease Friedreichâ??s ataxia (FRDA) is caused by hyperexpansion of GAAâ?¢TTC trinucleotide repeats within the first intron of the FXN gene, encoding the mitochondrial protein frataxin. Long GAAâ?¢TTC repeats causes heterochromatin-mediated silencing and loss of frata...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-22651 | biostudies-arrayexpress
TranscriptomicsTriplet nucleotide repeat-based siRNAs are highly toxic to cancer cells
Triplet repeat siRNAs as found amplified in diseases such as Huntingtons disease can be used to kill cancer cells
ORGANISM(S): Homo sapiens 
2018-01-12 | GSE104552 | GEO
ProteomicsThe CGG triplet repeat binding protein 1 counteracts DNA secondary structure formation to prevent transcription-replication stress
Short tracts of trinucleotide repeats with less than 10 repeats are found frequently throughout the genome without any apparent negative impact on DNA replication fork progression or transcription elongation. CGG binding protein 1 (CGGBP1) binds to CGG triplet repeats and has been implicated in mult...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD045654 | Pride
Transcription-replication conflicts Genomic instability Cggbp1 R-loop structure Cgg-trinucleotide repeats Replication stress Transcription regulation Dna damag G-quadruplex structure 
TranscriptomicsFriedreich’s Ataxia Induced Pluripotent Stem Cells Recapitulate GAA•TTC Triplet-Repeat Instability
The inherited neurodegenerative disease Friedreich’s ataxia (FRDA) is caused by hyperexpansion of GAA•TTC trinucleotide repeats within the first intron of the FXN gene, encoding the mitochondrial protein frataxin. Long GAA•TTC repeats causes heterochromatin-mediated silencing and loss of frataxin in...
ORGANISM(S): Homo sapiens 
2010-07-02 | GSE22651 | GEO
UnknownDNA repair and DNA triplet repeat expansion: the impact of abasic lesions on triplet repeat DNA energetics.
Not available
S-EPMC2705181 | biostudies-literature
GenomicsEffect of CWG-cPIP on CAG/CTG triplet repeat mouse brain
Effect of CWG-cPIP on CAG/CTG triplet repeat mouse brain
PRJNA867693 | ENA
UnknownHeterogeneous migration routes of DNA triplet repeat slip-outs.
Not available
S-EPMC9586884 | biostudies-literature
GenomicsIllumina HiSeqX whole genome sequence data on 58 samples including 54 with known HTT triplet repeat expansions (2 premutation and 52 full expansions)
Whole genome sequence (WGS) data was generated on 58 samples with validated repeat lengths for the CAG repeat associated with Huntington disease, These samples were sequenced using 2x150bp reads on an Illumina HiSeqX sequencer and the repeat expansions were called using ExpansionHunter to demonstrat...
EGAS00001002593 | EGA
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