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MetabolomicsGlobal Metabolic Analysis Trisomy 21 - Cohort 2
Not available
ORGANISM(S): Homo sapiens 
ST001240 | MetabolomicsWorkbench
MetabolomicsGlobal Metabolic Analysis Trisomy 21 - Cohort 1
Not available
ORGANISM(S): Homo sapiens 
ST001243 | MetabolomicsWorkbench
MetabolomicsGlobal Metabolic Analysis Trisomy 21 - Cohort 3, CSF
Not available
ORGANISM(S): Homo sapiens 
ST001242 | MetabolomicsWorkbench
MetabolomicsGlobal Metabolic Analysis Trisomy 21 - Cohort 3, Plasma
Not available
ORGANISM(S): Homo sapiens 
ST001241 | MetabolomicsWorkbench
ProteomicsConsequences of aneuploidy in human fibroblasts
To characterize aneuploidy driven phenotypes in human trisomies, we performed global transcriptome, proteome, and phenotypic analysis of primary human fibroblasts from individuals with Patau (trisomy 13), Edwards (trisomy 18), or Down syndromes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-09 | MSV000085706 | MassIVE
TranscriptomicsGene expression of human isogenic trisomy 21 induced pluripotent stem cells and derived neurons
Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-48611 | biostudies-arrayexpress
TranscriptomicsModelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21 [RNA-seq]
Down syndrome (trisomy 21) is the most common viable chromosomal disorder with intellectual impairment and several other developmental abnormalities. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from monozygotic twins discordant for trisomy 21...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52249 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fetal cerebellum, heart, cerebrum, and cerebrum derived astrocyte cell line from trisomy 21 and trisomy 13 samples
Gene expression was measured in trisomy 21 and trisomy 13 human fetal samples. For TS21, regions assayed were cerebrum, cerebellum, heart, and cerebrum-derived astrocyte cell lines.
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1397 | biostudies-arrayexpress
TranscriptomicsDistinct DNA methylation patterns of cognitive impairment and Trisomy 21 in Down Syndrome
The presence of an extra whole or part of chromosome 21 in people with Down syndrome (DS) is associated with multiple neurological changes, including pathological aging that often meets the criteria for Alzheimer’s Disease (AD). While the mechanism underlying these changes is unknown, it has been hy...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-50586 | biostudies-arrayexpress
TranscriptomicsTrisomy 21 consistently activates the interferon response
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-79843 | biostudies-arrayexpress
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