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MetabolomicsMetabolic effect of the loss of mitochondrial-specific aspartyl-tRNA synthetase Das2 on mouse intestinal epithelial cells
Not available
ORGANISM(S): Mus musculus 
ST002184 | MetabolomicsWorkbench
MetabolomicsMultiple modes of interfering with the activity of Plasmodium falciparum cytoplasmic isoleucyl-tRNA synthetase illustrate the enzyme is a promising antimalarial target.
Not available
ORGANISM(S): Plasmodium falciparum 
ST002078 | MetabolomicsWorkbench
ProteomicsYeast glutamine tRNA synthetase doxycycline shut-off
During protein synthesis, charged tRNAs deliver amino acids to translating ribosomes, and are then re-charged by tRNA synthetases (aaRS). In humans, mutant aaRS cause a diversity of neurological disorders, but their molecular aetiologies are incompletely characterised. To understand system responses...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-12 | PXD017140 | Pride
Saccharomyces cerevisiae Silac Translation Trna synthetase depletion 
ModelsMcFarland2020 - Synthetase sequestration Model:a combined translation and tRNA charging cycle
The Synthetase Sequestration Model (SSM) is a simplified translation model that considers explicitly two main steps in the process of tRNA aminoacylation: first, the tRNA is bound by the aminoacyl tRNA synthetase, and in a second step, the amino acid is attached to the tRNA. The tRNA then participat...
2020-02-05 | MODEL2001080005 | BioModels
TranscriptomicsRibo-seq of HEK293T overexpressing WT and G240R GARS
Charcot-Marie-Tooth (CMT) disease can be caused by mutations in Aminoacyl-tRNA-Synthetases, including G240R mutation in Glycyl-tRNA-Synthetase (GARS). Ribo-seq generates snapshots of translating ribosomes on mRNA and therefore allows analysis of ribosome pausing mRNA. Here we performed Ribo-seq on l...
ORGANISM(S): Homo sapiens 
2021-09-14 | E-MTAB-10342 | biostudies-arrayexpress
ProteomicsGel LC-MS/MS analyses of MMP cleavage of tryptophanyl-tRNA synthetase
Tryptophanyl-tRNA synthetase was incubated by MMPs, cleavage products were resolved on SDS-PAGE. Cleavage products were trypsin digested and analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-05-29 | PXD013217 | Pride
Mmp Protease Lc-ms/ms 
UnknownDouble mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Not available
S-EPMC5741666 | biostudies-literature
TranscriptomicsA growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo
Argonaute/Piwi proteins associate with small RNAs that typically provide sequence specificity for RNP function in gene and genome regulation. Here we show that Twi12, a Tetrahymena Piwi protein essential for growth, is loaded with mature tRNA fragments. The tightly bound ~18-22 nt tRNA 3M-bM-^@M-^Y ...
ORGANISM(S): Tetrahymena thermophila 
2010-10-26 | E-GEOD-24916 | biostudies-arrayexpress
TranscriptomicstRNA fragment profiling in CLP1 mutant (kinase-dead) mice
Loss of CLP1 activity results in the accumulation of novel sets of small RNA fragments derived from aberrant processing of tyrosine pre-tRNA. Such tRNA fragments sensitize cells to oxidative stress-induced p53 activation and p53-dependent cell death. 2 samples, Wt and Clp1(k/k), no replicates
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-39275 | biostudies-arrayexpress
GenomicstRNA sequestration triggers tyrosyl-tRNA synthetase-associated peripheral neuropathy
tRNA sequestration triggers tyrosyl-tRNA synthetase-associated peripheral neuropathy
PRJNA1115140 | ENA
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