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TranscriptomicsDown-regulation of SFRP1 in a mammary epithelial cell line
Microarray data to accompany Gauger et al. (2009) Cancer Cell International paper A treated X untreated design was used whereby immortalized human mammary epithelial cell lines (TERT cells) were modified to stably express an siRNA that knocked down SFRP1 expression. These "treated" cells were label...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-15948 | biostudies-arrayexpress
TranscriptomicsActivation of Host Wound Responses in Breast Cancer Microenvironment
Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or "wounds that do not heal," and gene expression signatures reflective of wound repair have shown value as predictors of breast cancer s...
ORGANISM(S): Homo sapiens 
2010-01-06 | E-GEOD-16113 | biostudies-arrayexpress
TranscriptomicsSystematic Bias in Genomic Classification Due to Contaminating Normal Tissue in Breast Tumor Samples
Results: Normal tissue contamination caused misclassification of tumors in all predictors, but different breast cancer predictors showed different susceptibility to normal tissue bias. Sensitivity and negative predictive value (NPV) of the PAM50 assay was improved by accounting for normal tissue. C...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-22384 | biostudies-arrayexpress
TranscriptomicsRelationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer
Purpose: Previous studies of breast tissue gene expression have demonstrated that the extratumoral microenvironment has substantial variability across individuals, some of which can be attributed to epidemiologic factors. To evaluate how mammographic density (MD) and breast tissue composition relat...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-49175 | biostudies-arrayexpress
TranscriptomicsNormal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression
Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have seldom been studied in association with obesity. Gene expres...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-33526 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling in the Carolina Breast Cancer Study
A microarray targeting promoters of cancer-related genes was used to evaluate DNA methylation at 935 CpG sites in 517 invasive breast tumors from the Carolina Breast Cancer Study (CBCS), a population-based study of invasive breast cancer. Concensus clustering using methylation (β) values for the 16...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-51557 | biostudies-arrayexpress
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