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TranscriptomicsCEA_SGF:E00005#LIF
In order to identify the genes involved in LIF/gp130 self-renewal response, we analyzed the transcriptome of Gs2 ES cells induced to differentiate upon LIF withdrawal for 16h, 24h and 48h (LIF16, LIF24 and LIF48 respectively)and compared them to that of undifferentiated ES Gs2 cells continuously mai...
ORGANISM(S): Mus musculus 
2004-07-01 | E-GEOD-1150 | biostudies-arrayexpress
TranscriptomicsCEA_SGF:E00004#TetOFF_Stat3F
The goal of this study was to identify the target genes of Stat3 involved in murine ES cell self-renewal. To achieve this goal, we used the Gs2 ES cell line expressing an inducible dominant negative mutant of Stat3 (Stat3F) in wich Y705 is mutated to phenilalanine. The Gs2 ES cells are routinely mai...
ORGANISM(S): Mus musculus 
2004-07-01 | E-GEOD-1151 | biostudies-arrayexpress
TranscriptomicsCEA_SGF:E00002#REtsAF-Bcl2_ZVAD
p53 can induce apoptosis through multiple mechanisms including transactivation, transrepression or protein interactions but the determinism of the choice between them is poorly understood. In order to know the role of caspases in this choice, effect of caspase inhibition by ZVAD on p53 target genes ...
ORGANISM(S): Mus musculus 
2004-06-01 | E-GEOD-1109 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tetraploid and polyploid (8N and 16N) megakaryocytes to identify genes which are up and down regulated during megakaryocyte differentiation/polyploidization
The aim of the experiment was to characterize by a pan-genomic approach genes which are continuously up and down regulated during polyploidization during megakaryocyte differentiation.
ORGANISM(S): Homo sapiens 
2007-04-16 | E-TABM-133 | biostudies-arrayexpress
TranscriptomicsCEA_SGF:E00009#switch_lympho_mega
we analyzed the gene expression profile of newly produced transgenic bone marrow subpopulations and compared it to the expression patterns obtained from cells isolated from wild type mice at different stages of the hematopoietic differentiation process. These populations were enriched in HSC, CMP, C...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-1289 | biostudies-arrayexpress
TranscriptomicsCEA_SGF:E00008#transgenic_IIb-tk
To investigate genes that are involved in hematopoietic cells production in vivo, we used microarray technology combined with a transgenic mouse model IIb-tk previously developed in our laboratory (Tropel et al., 1997). In these mice, the promoter region of the murine CD41 (GPIIb) gene was used to t...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-1290 | biostudies-arrayexpress
TranscriptomicsCEA_SGF:E00020#Dose_Effect_Blood
In this study, we asked whether expression profiling could generate a “signature” of a dose of exposure to a toxic in general and to gamma rays in particular. To characterize genes that could potentially “sign” an exposure to irradiation and could allow the estimation of the received dose, w...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-1889 | biostudies-arrayexpress
TranscriptomicsCEA_SGF:E00011#FGF6_effect
By using Hoechst staining techniques, we have previously shown that the C2C12 myogenic cell line contains a Side Population (SP) (Benchaouir et al, Exp Cell res, 2004) which is largely increased in the presence of FGF6 (Israeli et al, J Cellular Physiol, 2004). The experiment, compared transcription...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-1436 | biostudies-arrayexpress
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