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ProteomicsProteomic profiling of conditioned medium from rotational trophoblast organoids (hTOr)
Proteomic profiling of hTOr-conditioned medium was performed to characterize the secretome of rotational trophoblast organoids derived from human trophoblast stem cells. Collected supernatants underwent albumin depletion, followed by protein digestion using a Lys-C/trypsin mixture. The resulting pep...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD075393 | Pride
Proteomics Dia Human trophoblast organoids Secretome Placenta 
TranscriptomicsscRNA-seq and snucRNA-seq of human primary trophoblast organoids (PTO) and trophoblast stem cells (TSCs) differentiation into extravillous trophoblast organoids (EVTs)
This study aims to compare in vivo human trophoblast differentiation into EVTs to different in vitro trophoblast organoids using single-cell and single-nuclei RNA sequencing. The study includes two type of systems: human primary trophoblast organoids (PTO) and trophoblast stem cells (TSCs). Tropho...
ORGANISM(S): Homo sapiens 
2023-02-09 | E-MTAB-12650 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human trophoblast organoids EVT-differentiated in 21%, 8%, and 3% oxygen
Placental development occurs in a low oxygen environment, yet how oxygen tension instructs differentiation of progenitor cytotrophoblasts (CTB) along the extravillous versus villous pathways remains incompletely understood. In particular, the role of low oxygen in early extravillous trophoblast (EVT...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-16328 | biostudies-arrayexpress
TranscriptomicsscRNAseq of human embryo-derived trophoblast organoids and trophoblast stem cells
scRNAseq of human embryo-derived trophoblast organoids and trophoblast stem cells
ORGANISM(S): Homo sapiens 
2026-07-10 | E-MTAB-15376 | biostudies-arrayexpress
ProteomicsSecretome of trophoblast organoids
Characterisation of the secretome of placental organoids using Liquid Chromatography and Mass Spectrometry by performing solid phase extraction of the supernatants, followed by tryptic digestion.
ORGANISM(S): Homo sapiens (Human) 
2018-11-29 | PXD009118 | Pride
Secretion Lc-ms Trophoblast organoids Solid phase extraction 
TranscriptomicsCharacterization of primary models of human trophoblast
To understand the human placenta development, we investigated the features of two trophoblast models, trophoblast organoids and trophoblast stem cells, with the aim of identifying which type of trophoblast in vivo they most closely resemble. To this end, we profiled the transcriptomes from the two m...
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-10429 | biostudies-arrayexpress
TranscriptomicsCharacterization of primary models of human trophoblast
To understand the human placenta development, we investigated the features of two trophoblast models, trophoblast organoids and trophoblast stem cells, with the aim of identifying which type of trophoblast in vivo they most closely resemble. To this end, we profiled the microRNAs from the two models...
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-10438 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi.
The aim of this microarray experiment was to compare the overall transcriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi. As the placental villi contains both trophoblast and stromal populations, we have included placenta derive...
ORGANISM(S): Homo sapiens 
2018-11-28 | E-MTAB-6683 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of human trophoblast organoids providing a model for maternal-fetal interactions in early pregnancy and placenta tissue for comparison
Generation of long-term, genetically-stable organoid cultures of extra-embryonic fetal trophoblast cells from human early placentas. Methylation profiling of the human trophoblast organoids and early placenta tissue.
ORGANISM(S): Homo sapiens 
2018-11-28 | E-MTAB-7204 | biostudies-arrayexpress
TranscriptomicsHuman uterine Natural Killer cells regulate differentiation of extravillous trophoblast early in pregnancy - scRNA-seq data
We used trophoblast organoids differentiating to extravillous trophoblast (EVT) to study the effects of key cytokines secreted by uterine Natural Killer (uNK) cells on EVT behaviour. Specifically, we exposed the organoids to four uNK-derived cytokines (CSF1, CSF2, XCL1, CCL5) and collected cells at ...
ORGANISM(S): Homo sapiens 
2024-01-10 | E-MTAB-13382 | biostudies-arrayexpress
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