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TranscriptomicsTime course bulk RNA-seq of Troy+ chief cells in the mouse stomach corpus epithelium after injury
The purpose of this experiment is to assess temporal transcriptomic change in Troy+ chief cells upon injury in the stomach corpus in mice. Troy+-eGFP cells were sorted at each time point after stomach injury by DMP777 treatment.
ORGANISM(S): Mus musculus 
2022-05-05 | E-MTAB-10373 | biostudies-arrayexpress
TranscriptomicsExpression Profiling E. Coli Evolved on Glucose Minimal Media
mRNA sequencing was performed on E. coli evolved at 37C on M9 Minimal Media with Glucose Growth of evolved E. coli was characterized under the same conditions as the evolution and compared to the wild type parent strain
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-12-03 | E-GEOD-61327 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of environmental Escherichia coli isolates indicates highly conserved ecophysiology
Escherichia coli, the common inhabitant of the mammalian intestine, exhibits considerable intraspecies genomic variation, which has been suggested to reflect adaptation to different ecological niches. Also, regulatory trade-offs, e.g., between catabolic versatility and stress protection, are thought...
ORGANISM(S): Escherichia coli 
2006-12-04 | E-GEOD-6407 | biostudies-arrayexpress
TranscriptomicsWhite Cells Facilitate Opposite- and Same-Sex Mating of Opaque Cells in Candida albicans
Modes of sexual reproduction in eukaryotic organisms are highly diversified. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally and morphologically differentiated ...
ORGANISM(S): Candida albicans 
2014-10-23 | E-GEOD-56039 | biostudies-arrayexpress
TranscriptomicsAdaptively evolved yeast mutants on galactose shows trade-offs in carbon utilization on glucose.
Exploring molecular details of carbon utilization trade-offs in galactose-evolved yeast Adaptively evolved yeast mutants on galactose for around 400 generations showed diminished growth and carbon uptake rates on glucose. Genome-scale approaches were applied to characterize the molecular genetic ba...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-31 | E-GEOD-39065 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of Immunity- and Reproduction-related Differential Gene Expression in Parasitized Locusta migratoria
The transcriptome and DGE analysis of the fat body and ovary of L. migratoria based on the Illumina short-read sequencing technology and De novo assembly. Research on the trade-offs between immunity and reproduction is contributing significantly to the understanding of the fitness of organisms in na...
ORGANISM(S): Locusta migratoria 
2017-05-01 | E-GEOD-57437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of cerebella from Sbno2-/- mice
This study sought to investigate the role of Strawberry notch homolog 2 (Sbno2), an interleukin-6 (IL-6)-regulated gene whose function is largely unknown, in the central nervous system through the use of a novel mouse model with germline deletion of Sbno2 (Sbno2-/-). In particular, to understand its...
ORGANISM(S): Mus musculus 
2022-05-25 | E-MTAB-11169 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of fetal lamb heart treated with coiled implantation in left atrium against untreated controls
We created a fetal lamb model of hypoplastic left heart syndrome (HLHS), by implanting coils in the left atrium in mid-gestation. We performed bulk RNA sequencing of left ventricles (LV), right ventricles (RV), ascending aortae (AAo) and pulmonary arteries (PA). Single nucleus RNA sequencing was per...
ORGANISM(S): Ovis aries 
2023-05-31 | E-MTAB-12230 | biostudies-arrayexpress
TranscriptomicsMSN2-mCherry vs. msn2 microarray
Transcriptional profiling of Msn2 regulated genes. Both strains are PKAas (TPK1M164G TPK2M147G TPK3M165G) and msn4-delta. One strain has Msn2 C-terminally tagged with mCherry and the other strain is msn2-delta. In this experiment, both strains were exposed to 3 uM 1-NM-PP1, which leads to Msn2 nucle...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-12 | E-MTAB-1945 | biostudies-arrayexpress
GenomicsMsn2-mediated nucleosome remodeling dynamics
The aim of this experiment was to determine, using MNAse-Seq, how nucleosomes get remodeled during an Msn2 activation timecourse genome-wide. Diploid strain EY2807/ASH79 with genotype TPK1M164G TPK2M147G TPK3M165G msn4::TRP1/LEU2 MSN2-mCherry NHP6a-iRFP::kanMX was used. This strain is PKAas, so upon...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-12 | E-MTAB-1950 | biostudies-arrayexpress
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