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TranscriptomicsTranscription profiling of mouse dendritic subsets in vivo
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6259 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of human tumor digests treated with Toll-like receptor agonists and interferons against untreated controls
To test whether dendritic cells from patient-derived tumor digests can be activated by agonists and which genes are regulated, we performed a single-cell RNA-seq of immune cells (CD45+) from 4 donors.
ORGANISM(S): Homo sapiens 
2022-06-15 | E-MTAB-11734 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of human blood dendritic cells from buffy coats and in vitro differentiated dendritic cells from cord blood CD34 + stem cells
To compare human dendritic cells from peripheral blood, in vitro cultures with dendritic cells from human tumor tissues in publicly available single-cell RNA-seq datasets we performed single-cell RNA-seq of human blood dendritic cells and in vitro differentiated dendritic cells from cord blood CD34 ...
ORGANISM(S): Homo sapiens 
2022-06-15 | E-MTAB-11735 | biostudies-arrayexpress
TranscriptomicsSynthetic double stranded RNA reliably induces innate immunity similar to a live viral vaccine in humans
Adjuvants are critical for the success of vaccines, and agonists for microbial pattern recognition receptors are promising new candidates. A mechanism for the immune enhancing role of adjuvants is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double stran...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32862 | biostudies-arrayexpress
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