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Transcriptomics3’-Seq of multipotent progenitor cells MPP5
Here, we present a 3'-Seq dataset of ex vivo isolated mouse multipotent progenitor cells MPP5
ORGANISM(S): Mus musculus 
2021-06-18 | E-MTAB-9135 | biostudies-arrayexpress
Transcriptomics3’-Seq HSC/MPP1-4
Here, we present a 3’-Seq dataset of ex vivo isolated mouse multipotent hematopoietic stem cells (HSC) and multipotent progenitor cells (MPP1-4)
ORGANISM(S): Mus musculus 
2020-06-01 | E-MTAB-7391 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA Seq of hematopoietic stem and progenitor cells
This dataset is part of a study that investigated how the hematopoietic system coordinates the rapid and efficient regeneration of the megakaryocytic lineage during stress scenarios. We found that the phenotypic hematopoietic stem cell (HSC) compartment contains stem-like megakaryocyte-committed pro...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-64002 | biostudies-arrayexpress
TranscriptomicsIFNa activates dormant HSCs in vivo
Maintenance of the blood system is dependent on dormant haematopoietic stem cells (HSCs) with long-term self-renewal capacity. Upon injury these cells are induced to proliferate in order to quickly re-establish homeostasis. The signalling molecules promoting the exit of HSCs out of the dormant stage...
ORGANISM(S): Mus musculus 
2009-01-15 | E-GEOD-14361 | biostudies-arrayexpress
TranscriptomicsMyc Depletion in Naïve ESCs Induces a Pluripotent Dormant State Mimicking Embryonic Diapause
Microarray expression analysis of mouse ESCs treated with the MYCi 10058-F4. Mouse ESCs were analysed after 60h of treatment with DMSO or 10058-F4 (MYCi). The MYCi⇒Released (Resc) group was treated with 10058-F4 for 60h, followed by withdrawal of the inhibitor and culture in 2i medium for addition...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-74337 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of primary mouse Neural Plate Border Stem Cells
We describe a so far uncharacterized, embryonic and self-renewing Neural Plate Border Stem Cell (NBSC) population with the capacity to differentiate into central nervous and neural crest lineages. NBSCs can be obtained by neural transcription factor-mediated reprogramming (BRN2, SOX2, KLF4, and ZIC3...
ORGANISM(S): Mus Musculus 
2018-12-20 | E-MTAB-6925 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of E8.5 stage embryonic neural tissue from mouse
We describe a so far uncharacterized, embryonic and self-renewing Neural Plate Border Stem Cell (NBSC) population with the capacity to differentiate into central nervous and neural crest lineages. NBSCs can be obtained by neural transcription factor-mediated reprogramming (BRN2, SOX2, KLF4, and ZIC3...
ORGANISM(S): Mus musculus 
2018-12-20 | E-MTAB-6912 | biostudies-arrayexpress
GenomicsHypermutation of the inactive X chromosome is a frequent event in cancer
Mutation is a fundamental process in tumorigenesis. However the degree to which the rate of somatic mutation varies across the human genome and the mechanistic basis underlying this variation remain to be fully elucidated. As part of the ICGC PedBrain and Malignant Lymphoma (MMML-Seq) consortium we ...
EGAS00001000565 | EGA
TranscriptomicsSingle cell RNA-sequencing of induced Neural Plate Border Stem Cells
We describe a so far uncharacterized, embryonic and self-renewing Neural Plate Border Stem Cell (NBSC) population with the capacity to differentiate into central nervous and neural crest lineages. NBSCs can be obtained by neural transcription factor-mediated reprogramming (BRN2, SOX2, KLF4 and ZIC3)...
ORGANISM(S): Homo sapiens 
2018-12-20 | E-MTAB-6911 | biostudies-arrayexpress
TranscriptomicsRNA seq of CD45.2+ Neo1 deficient or wildtype Hematopoietic stem cells, 4 or 15 month after stem cell transplantation
To study the role of the receptor Neo1 in Hematopoietic stem cells (HSC) we transplanted Neo1 deficient bone marrow and wildtype controls on a CD45.2 background into lethally irradiated CD45.1 recipients. Either 4 or 15 months after transplantation we isolated HSC (Lineage -, Sca-1+, c-Kit+, Cd150+,...
ORGANISM(S): Mus musculus 
2020-07-22 | E-MTAB-7902 | biostudies-arrayexpress
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