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MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12482 | MetaboLights
MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12483 | MetaboLights
ProteomicsOxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions
Raw data of the project "Oxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-18 | MSV000093891 | MassIVE
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
MetabolomicsGut Microbiota-Mediated Tryptophan Metabolism Plays Dual Effects in Diffuse Large B-Cell Lymphoma via Regulating 3-IAA/5-HTP Balance and Antitumor Immunity
Timing-dependent tryptophan diets differentially modulate DLBCL outcomes via microbiota-derived 3-IAA (pre-inoculation, anti-tumor) versus 5-HTP (post-inoculation, pro-tumor), with pectin restoring microbial balance to enable a timed tryptophan-pectin precision nutrition strategy for enhanced immuno...
2026-09-07 | MTBLS15570 | MetaboLights
UnknownRole of the tryptophan residue in the vicinity of the catalytic center of exonuclease III family AP endonucleases: AP site recognition mechanism.
Not available
S-EPMC1408312 | biostudies-literature
UnknownFunctional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy.
Not available
S-EPMC7005313 | biostudies-literature
UnknownIdentification of Tyr413 as an active site residue in the flavoprotein tryptophan 2-monooxygenase and analysis of its contribution to catalysis.
Not available
S-EPMC1630680 | biostudies-literature
UnknownSubstitution of a Surface-Exposed Residue Involved in an Allosteric Network Enhances Tryptophan Synthase Function in Cells.
Not available
S-EPMC8187860 | biostudies-literature
UnknownAnalysis of the role of the active site residue Arg98 in the flavoprotein tryptophan 2-monooxygenase, a member of the L-amino oxidase family.
Not available
S-EPMC1635017 | biostudies-literature
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