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ProteomicsImipridones cause cellular toxicity in human cells and bacteria by ectopic activation of the ClpP protease
Ectopic activation of the conserved ClpP protease by chemical activators causes toxicity in bacteria and human cells due to unrestrained proteolysis. The imipridone ONC201 has been ascribed multiple mechanisms of action and is currently in cancer clinical trials. To systematically investigate the ge...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2020-03-26 | PXD016119 | Pride
Imipridones Clpp protease 
UnknownAPOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.
Not available
S-EPMC8980930 | biostudies-literature
UnknownActionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Not available
S-EPMC7612986 | biostudies-literature
GenomicsWhole Genome and Exon Capture Sequencing of Bladder Cancers

One primary bladder cancer and paired peripheral blood sample were subjected to whole genome sequencing on an Illumina HiSeq 2000 platform. This technology was utilized to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a dru...

phs000535.v1.p1 | EGA
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