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TranscriptomicsRegulatory mechanisms of TSG-6 (TNF-alfa-induced protein-6: Tnfip6)-deficient and wild-type synovial fibroblasts
BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases susceptibility and local inflammatory reactions, including neutrophil invasion into the joints. To gain insight into the mechanisms of TSG-6 action, synovial fibroblasts wer...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-17160 | biostudies-arrayexpress
ProteomicsCo-IP/MS for determining interacting partners of TSG-6 in human pHSCs
Interacting partners of TSG-6 were analyzed by coimmunoprecipitation (co-IP) coupled with liquid chromatography tandem mass spectrometry (LC–MS/MS)
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047449 | Pride
Human Tsg-6 Primary hepatic stellate cells Co-ip/ms 
TranscriptomicsRNAseq of epidermis reconstructed from TSG-6-/- and TSG-6+/+ immortalized N/TERT keratinocytes and stimulated or not with interleukins 4 and 13 for 48h
TNFα-stimulated gene 6 (TSG-6) is an anti-inflammatory protein. In human epidermis, TSG-6 is secreted in extracellular matrix where it interacts with hyaluronan (HA). However, their functions are not well understood. In this study, immortalized N/TERT keratinocytes were edited by CRISPR/Cas9, used t...
ORGANISM(S): Homo sapiens 
2021-12-30 | E-MTAB-10095 | biostudies-arrayexpress
GenomicsRNAseq of epidermis reconstructed from TSG-6-/- and TSG-6+/+ immortalized N/TERT keratinocytes and stimulated or not with interleukins 4 and 13 for 48h
RNAseq of epidermis reconstructed from TSG-6-/- and TSG-6+/+ immortalized N/TERT keratinocytes and stimulated or not with interleukins 4 and 13 for 48h
PRJEB43041 | ENA
GenomicsTranscriptome changes after TSG-6 treatment of mouse liver fibrosis.
Transcriptome changes after TSG-6 treatment of mouse liver fibrosis.
PRJNA498069 | ENA
GenomicsTSG-6 mediated extracellular matrix modifications regulate hypoxic-ischemic brain injury
TSG-6 mediated extracellular matrix modifications regulate hypoxic-ischemic brain injury
PRJNA1047137 | ENA
TranscriptomicsRegulatory mechanisms of TSG-6 (TNF-alfa-induced protein-6: Tnfip6)-deficient and wild-type synovial fibroblasts
BALB/c mice are susceptible to proteoglycan (PG) aggrecan-induced arthritis (PGIA), and the absence of TSG-6 further increases susceptibility and local inflammatory reactions, including neutrophil invasion into the joints. To gain insight into the mechanisms of TSG-6 action, synovial fibroblasts wer...
ORGANISM(S): Mus musculus 
2011-07-05 | GSE17160 | GEO
TranscriptomicsTranscriptome changes after TSG-6 treatment of mouse liver fibrosis.
Our previous studies revealed that exogenous administration of TSG-6 can ameliorate liver fibrosis. We next analyzed liver transcriptome changes after TSG-6 treatment in order to explore possible therapeutic changes.
ORGANISM(S): Mus musculus 
2021-10-23 | GSE121669 | GEO
UnknownThe inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers.
Not available
S-EPMC3138277 | biostudies-literature
GenomicsTSG-6 supports fistulizing Crohn’s disease by a mechanoregulated activation of the epithelial-to-mesenchymal transition
TSG-6 supports fistulizing Crohn’s disease by a mechanoregulated activation of the epithelial-to-mesenchymal transition
PRJNA659792 | ENA
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