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TranscriptomicsExpression data from MCF-7 cells stimulated by Estrogen or IGF-I
Although estrogen receptor (ER) and insulin-like growth factor (IGF) signaling are important for normal mammary development and breast cancer, cross-talk between these pathways, particularly at the level of gene transcription, remains poorly understood. We performed microarray analysis on MCF-7 bre...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-26834 | biostudies-arrayexpress
TranscriptomicsSAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells
The scaffold attachment factors SAFB1 and SAFB2 are paralogs, which are involved in cell cycle regulation, apoptosis, differentiation, and stress response. They have been shown to function as estrogen receptor co-repressors, and there is evidence for a role in breast tumorigenesis. To identify their...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-15548 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary gland side population cells (MG-SPs) to identify differentially expressed genes.
Similar to the bone marrow, the mammary gland contains a distinct population of Hoechst-effluxing side population cells, MG-SPs. To better characterize MG-SPs, their microarray gene profiles were compared to the remaining cells, which retain Hoechst dye (MG-NSPs). For analysis, gene ontology (GO) t...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5309 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pre-malignant breast cancer samples
Enlargement of normal terminal duct lobular units (TDLUs) by hyperplastic columnar epithelial cells is one of the most common abnormalities of growth in the adult female human breast. These hyperplastic enlarged lobular units (HELUs) are important clinically as the earliest histologically identifia...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-7377 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumor-initiating cells
Using a syngeneic p53 null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified by limiting dilution transplantation as well as in vitro mammosphere and clonogenic assays a Lin-CD29HighCD24High subpopulation of tumor-initiating cells. Differentially expressed ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8863 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tamoxifen-resistant MCF-7 wild-type murine xenograft tumors with E2-supplemented tumors MCF7 xenografts
In order to help determine the genes involved in resistance of breast cancer to endocrine therapy, we compared global gene expression profiles of tamoxifen-resistant MCF-7 WT xenograft tumors with E2-supplemented tumors. Experiment Overall Design: MCF7 xenografts were established in ovariectomized f...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-7327 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human sensitive and resistant tumours identify gene expression patterns in primary breast-cancer specimens that might predict response to taxanes.
These patients proved resistant to docetaxel treatment, exhibiting residual tumor of 25% or greater remaining volume.
ORGANISM(S): Homo sapiens 
2007-10-04 | E-GEOD-349 | biostudies-arrayexpress
TranscriptomicsExpression Profiling Reveals Unexpected Targets and Functions of the Human Steroid Receptor RNA Activator (SRA) Gene
The human steroid receptor RNA activator (SRA) gene encodes both non-coding RNAs (ncRNAs) and protein-generating isoforms. However, the breadth of endogenous target genes that might be regulated by SRA RNAs remains largely unknown. To address this, we depleted SRA RNA in two human cancer cell lines ...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-20081 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer patients sensitive to docetaxel
These patients were sensitive to docetaxel treatment, exhibiting less than 25% residual tumor.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-350 | biostudies-arrayexpress
TranscriptomicsComprehensive genomic analysis identify novel subtypes and targets of triple-negative breast cancer (198 TNBC tumors)
Recent meta-analyses suggest triple-negative breast cancer (TNBC) is a heterogenous disease. In this study we sought to define these TNBC subtypes and identify subtype-specific markers and targets. We identified and confirmed four distinct, stable TNBC subtypes: (1) Luminal-AR (LAR); 2) Mesenchymal ...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-76124 | biostudies-arrayexpress
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