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TranscriptomicsGPR120 mediates high-fat diet induced obesity
Analysis of GPR120 which play roles for the fatty acid sensor in adipose tissue. Results provide insight into the transcriptional effects caused by the loss of the GPR120 proteins and provide further insight into their functions. GPR120 KO mice and the corresponding wild-type with normal diet(ND) or...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-32095 | biostudies-arrayexpress
TranscriptomicsTranscriptome expressed in the mouse suprachiasmatic nucleus
This array set was used to identify the genes that are highly expressed in the mouse suprachiasmatic nucleus (SCN). Because pharmacological inhibition of Gai/o activity with pertussis toxin hampers intercellular synchronization and causes dampened rhythms of the entire SCN, we hypothesized that memb...
ORGANISM(S): Mus musculus 
2011-04-22 | E-GEOD-28574 | biostudies-arrayexpress
TranscriptomicsTrastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells
Objective: Trastuzumab has been used for the treatment of HER2-positive breast cancer (BC). However, a subset of BC patients exhibited resistance to trastuzumab therapy. Thus, clarifying the molecular mechanism of trastuzumab treatment will be beneficial to improve the treatment of HER2-positive BC ...
ORGANISM(S): Homo sapiens 
2012-06-02 | E-GEOD-38415 | biostudies-arrayexpress
TranscriptomicsMicroRNA Profile Predicts Recurrence of Hepatocellular Carcinoma in Milan Criteria Cases with Mild Liver Cirrhosis.
In this study, we utilized microRNA expression profiling to assess risk of HCC recurrence after liver resection. We examined microRNA expression profiling in paired tumor and non-tumor liver tissues of 73 HCC patients with mild cirrhosis (Child-Pugh A/B) who satisfy Milan Criteria. We constructed pr...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-21362 | biostudies-arrayexpress
TranscriptomicsIdentification of EP4 as a Potential Target for the Treatment of Castration-Resistant Prostate Cancer Using a Novel Xenograft Model
More effective therapeutic approaches for castration-resistant prostate cancer (CRPC) are urgently needed, thus reinforcing the need to understand how prostate tumors progress to castration resistance. We have established a novel mouse xenograft model of prostate cancer, KUCaP-2, which expresses the...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21887 | biostudies-arrayexpress
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