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TranscriptomicsTranscription profiling of human umbilicial vein endothelial cells after TNF-alpha treatment
The many steps involved in the production of a mature mammalian mRNA are extensively coupled, and levels of both precursors and products can be measured using expression and genomic tiling microarrays. Different probes in these arrays targeting the same transcript often give different signals; then...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-9055 | biostudies-arrayexpress
GenomicsGenome wide analysis of AR binding sites and histone modifications in prostate cancer
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and histone modifications.In addition, by siRNA mediated knockdown of AR-associated factors, changes of AR-binding sit...
ORGANISM(S): Homo sapiens 
2015-02-08 | E-GEOD-62492 | biostudies-arrayexpress
TranscriptomicsExpression data of human lung adenocarcinoma cell line H441 treated with TTF-1/NKX2-1 siRNA and TGF-beta
We determined and analyzed the effect of TTF-1/NKX2-1 on Smad3/Smad4 binding sites by ChIP-sequencing. We used expression microarrays to evaluate the effect of TTF-1/NKX2-1 siRNA on TGF-beta-induced gene expressions. H441 cells were transfected with siRNAs and treated with TGF-beta for RNA extractio...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-49675 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 36 types of normal human tissues to identify tissue-specific genes
We performed expression profiling of 36 types of normal human tissues and identified 2,503 tissue-specific genes. We then systematically studied the expression of these genes in cancers by re-analyzing a large collection of published DNA microarray datasets. Our study shows that integration of each ...
ORGANISM(S): Homo sapiens 
2005-04-03 | E-GEOD-2361 | biostudies-arrayexpress
TranscriptomicsExpression data of HUVEC cells after TNF-alpha treatment
Tumor necrosis factor a (TNF-aplha) is a potent cytokine that orchestrates the inflammatory response by sequentially activating the expression of many genes in cultured human umbilical vein cells (HUVECs). We apply samples collected every 7.5 min to arrays and monitor the growth of several long tran...
ORGANISM(S): Homo sapiens 
2007-09-19 | E-GEOD-9036 | biostudies-arrayexpress
TranscriptomicsEffect of TTF-1/NKX2-1 expression on TGF-beta induced gene expression in A549 lung cancer cell line.
TTF-1/NKX2-1 was expressed by adenoviral vector and changes in gene expression were determined by RNA-sequencing. A549 cells were infected with Ad-TTF-1 or Ad-LacZ vectors and stimulated with TGF-beta for 24 hours or left untreated. Expression of polyA RNA was determined.
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-56356 | biostudies-arrayexpress
GenomicsSmad3, Smad4 and TTF-1/NKX2-1 binding sites in H441/A549 lung cancer cell lines
We evaluated the role of TTF-1/NKX2-1 on Smad3 and Smad4 binding in lung cancer cell lines. Smad3 binding sites in A549 cells and Smad3, Smad4, and TTF-1/NKX2-1 binding sites in H441 cells were determined by ChIP-seq.
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-51509 | biostudies-arrayexpress
TranscriptomicsExpression data of the human hepatoblastoma cell line HepG2 treated with TGF-beta
Smad2/3 are transcription factors that engage in TGF-beta-induced transcription. We determined and analyzed HepG2 and Hep3B-specific Smad2/3 binding sites by ChIP-chip. We used expression microarrays to compare the Smad2/3 and HNF4alpha binding sites identified by ChIP-chip or ChIP-seq, respectively...
ORGANISM(S): Homo sapiens 
2011-06-08 | E-GEOD-28590 | biostudies-arrayexpress
TranscriptomicsExpression data of human pulmonary arterial smooth muscle cells (PASMCs) treated with BMP-4
Smad1/5 are transcription factors that engage in BMP-induced transcription. We determined and analyzed Smad1/5 binding sites by ChIP-sequencing. We used expression microarrays to compare the Smad1/5 binding sites identified by ChIP-seq to BMP-induced gene expressions. PASMCs were treated with 50 ng/...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-28847 | biostudies-arrayexpress
TranscriptomicsExpression data of human umbilical vein endothelial cells (HUVECs) treated with BMP-6 and BMP-9
Smad1/5 are transcription factors that engage in BMP-induced transcription. We determined and analyzed Smad1/5 binding sites by ChIP-sequencing. We used expression microarrays to compare the Smad1/5 binding sites identified by ChIP-seq to BMP-induced gene expressions. HUVECs were treated with BMP fo...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-27631 | biostudies-arrayexpress
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