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TranscriptomicsGenome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a M-bM-^@M-^\cleavable complexM-bM-^@M-^]. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment aff...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-48678 | biostudies-arrayexpress
GenomicsGenome-wide map of p53 binding sites by ChIP-seq in human lymphoblastoid cell lines treated with doxorubicin
We have used chromatin immune-precipitation with parallel sequencing (ChIP-Seq) technology to identify genome-wide p53 binding in human lymphoblastoid cell lines treated with a DNA-damaging chemotherapeutic reagent doxorubicin. ChIP-Seq analysis of p53 binding sites in human lymphoblastoid cells tre...
ORGANISM(S): Homo sapiens 
2013-10-23 | E-GEOD-46991 | biostudies-arrayexpress
GenomicsGenome-wide map of p53 binding sites by ChIP-seq in human lymphoblastoid cell lines treated with ionizing radiation
We have used chromatin immune-precipitation with parallel sequencing (ChIP-Seq) technology to identify genome-wide p53 binding in human lymphoblastoid cell lines treated withionizing radiation ChIP-Seq analysis of p53 binding sites in human lymphoblastoid cells treated with ionizing radiation or veh...
ORGANISM(S): Homo sapiens 
2013-10-23 | E-GEOD-46993 | biostudies-arrayexpress
GenomicsGenome-wide map of p53 binding sites by ChIP-seq in human lymphoblastoid cell lines treated with nutlin-3
We have used chromatin immune-precipitation with parallel sequencing (ChIP-Seq) technology to identify genome-wide p53 binding in human lymphoblastoid cell lines treated with a MDM2 inhibitor nutlin-3 ChIP-Seq analysis of p53 binding sites in human lymphoblastoid cells treated with nutlin-3 or vehic...
ORGANISM(S): Homo sapiens 
2013-10-23 | E-GEOD-46992 | biostudies-arrayexpress
TranscriptomicsDrosophila Gene Expression During Metamorphosis in Wild Type and Germline Minus Pupae
Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. G...
ORGANISM(S): Drosophila melanogaster 
2009-02-10 | E-GEOD-11313 | biostudies-arrayexpress
UnknownDiscovery of structural deletions in breast cancer predisposition genes using whole genome sequencing data from > 2000 women of African-ancestry.
Not available
S-EPMC9109261 | biostudies-literature
GenomicsAmplicon-Screening of exonic DNA regions in exon-wide mutant cell libraries of mutant TP53 (Exons 5, 6, 7, 8) in HCT116 cells generated via CRISPR editing
To compare the impact of TP53 mutant variants in exon-wide mutant cell libraries, comprehensive mutome libraries of TP53 affecting the Exons 5, 6, 7 and 8 were generated systematically by CRISP/Cas9 editing in HCT116 colorectal carcinoma cells.
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-12857 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq of haploidized HCT116 colorectal carcinoma cells expressing specific p53 mutations treated with either DMSO or Nutlin
Colorectal carcinoma cell line HCT116 cells were used as a model system to investigate the heterogeneity of different TP53 mutations. To this end, cells were haploidized by deleting an intronic splice site in one of the two wild-type TP53 alleles while the other copy was altered to different loss-of...
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-13904 | biostudies-arrayexpress
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