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MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
MetabolomicsMouse kidney metabolomics (Proximal tubular cells)
Not available
ORGANISM(S): Mus musculus 
ST002458 | MetabolomicsWorkbench
TranscriptomicsC-peptide regulates early transcription in rat proximal tubular cells
C-peptide exerts beneficial effects on glomerular hyperfiltration in type I diabetic patients. As C-peptide localizes to the nucleus, we investigated the transcriptional activities of C-peptide in proximal tubular cells isolated from diabetic rats. Two groups of proximal tubular cells isolated from ...
ORGANISM(S): Rattus norvegicus 
2011-07-26 | E-GEOD-24687 | biostudies-arrayexpress
TranscriptomicsD11.5 Tubular Porcine Conceptus
Transcriptome profiling of in vivo-derived porcine conceptus at the tubular stage (12-80 mm) during the elongation period of peri-implantation development. Keywords: Embryo stage of development Transcriptome profiling of in vivo derivied porcine conceptuses at critical stages of pre-implantation de...
ORGANISM(S): Sus scrofa 
2005-12-30 | E-GEOD-3875 | biostudies-arrayexpress
TranscriptomicsExpression data from renal primary epithelial cells
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in the ADPKD genes PKD1 and PKD2 account for nearly all the cases of ADPKD. Increased cell prolif...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-11500 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls
Tubular atrophy and interstitial fibrosis present the final stage in most forms of progressive kidney diseases. Little is known regarding the early changes in the tubular proteome. In this study, we investigated changes in the tubular proteome of normal or near-normal tubular tissue in the non-clipp...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-12-23 | PXD002106 | Pride
Tubules Ffpe Rat Kidney 
TranscriptomicsA Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity
A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity" Copyright (c) 2005 by Iconix Pharmaceuticals, Inc. Guidelin...
ORGANISM(S): Rattus norvegicus 
2005-11-30 | E-GEOD-3210 | biostudies-arrayexpress
Proteomicsmice Renal tubular epithelial cells LC-MS/MS
Diabetic nephropathy is considered one of the most common microvascular complications of diabetes and the pathophysiology involves multiple factors. Progressive diabetic nephropathy is believed to be related to the structure and function of the tubular epithelial cells in the kidney. However, the ro...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029651 | Pride
Mouse Renal tubular epithelial cells Lc-ms/ms 
TranscriptomicsTranscription profiling of human proximal tubular epithelial cells inclubated with 5% plasma from septic patients or healthy volunteers
proximal tubular epithelial cell apoptosis were incubated with 5% plasma of septic patients or healthy volunteers diluited in RPMI 1640
ORGANISM(S): Homo sapiens 
2008-03-15 | E-MEXP-1510 | biostudies-arrayexpress
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