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MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
MetabolomicsClusia genomes shed light on the evolution and diversity of CAM physiotypes

225 years ago, Alexander von Humboldt observed the first crassulacean acid metabolism (CAM) tree, Clusia rosea (Clusiaceae). Since then, the photosynthetic and ecophysiological plasticity of Clusia

species have captivated the minds of plant scientists worldwide. CAM is a physiological adapt...

2026-03-23 | MTBLS14075 | MetaboLights
MetabolomicsChitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle.
Marine picocyanobacteria Prochlorococcus and Synechococcus, the most abundant photosynthetic cells in the oceans, are generally thought to have a primarily single-celled and free-living lifestyle. However, while studying the ability of picocyanobacteria to supplement photosynthetic car...
2024-02-21 | MTBLS5229 | MetaboLights
TranscriptomicsExploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
In this study, using a murine model of Ph+ acute lymphoblastic leukemia (Ph+ ALL), a combined pharmacological profile and drug selection experimental approach identified distinct stages of tumor clonal evolution with vulnerabilities to sets of small molecules. Through genotypic, phenotypic, signalin...
ORGANISM(S): Mus musculus 
2016-04-05 | E-GEOD-72910 | biostudies-arrayexpress
MetabolomicsActivated ATF6α is a hepatic tumor driver restricting immunosurveillance

Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF...

2025-11-17 | MTBLS13241 | MetaboLights
TranscriptomicsRAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors
Aberrant Shh signaling promotes tumor growth in diverse human cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the Shh pathway component Smoothened (Smo) show great therapeutic promise. However, the emergen...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-69359 | biostudies-arrayexpress
ProteomicsAPOBEC mutagenesis and copy number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors
Intratumor mutational heterogeneity has been documented in primary non-small cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using whole-exome and transcriptome sequencing, SNP array for cop...
ORGANISM(S): Homo sapiens (Human) 
2019-05-07 | PXD012845 | Pride
Proteomics Tumor heterogeneity rapid autopsy 
TranscriptomicsClonal evolution and devolution following chemotherapy in adult acute myelogenous leukemia
The frequent occurrence of persistent or relapsed disease following induction chemotherapy in AML necessitates a better understanding of the clonal relationship of AML in various disease phases. In this study, we employed SNP 6.0 array-based genomic profiling of acquired copy number aberrations (aCN...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-41646 | biostudies-arrayexpress
GenomicsHeterogeneous immune and tumor clonal evolution patterns in liver cancer
Paired end whole exome sequencing for patient 10, matched normal and tumor
ORGANISM(S): Homo sapiens 
2020-02-01 | E-MTAB-8127 | biostudies-arrayexpress
TranscriptomicsAdaptive evolution in yeast
A Saccharomyces cerevisiae population was cultured for many generations under conditions to which it is not optimally adapted. These experiments were designed to investigate adaptive evolution under natural selection. This study is described in more detail in Ferea TL, et al. 1999. Proc Natl Acad Sc...
ORGANISM(S): Saccharomyces cerevisiae 
2002-02-11 | E-GEOD-29 | biostudies-arrayexpress
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