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TranscriptomicsGene Expression Changes in a Tumor Xenograft by a Py-Im Polyamide
Gene regulation by DNA binding small molecules could have important therapeutic applications. This study reports the investigation of a DNA-binding pyrrole-imidazole polyamide targeted to bind the DNA sequence 5M-bM-^@M-^Y-WGGWWW-3M-bM-^@M-^Y with reference to its potency in a subcutaneous xenograft...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-40218 | biostudies-arrayexpress
TranscriptomicsComparative oncogenomics identifies breast tumors enriched in functional tumor initiating cells
The claudin-low subtype is a recently identified rare molecular subtype of human breast cancer that expresses low levels of tight and adherens junction genes and shows high expression of epithelial-to-mesenchymal transition (EMT) genes. These tumors are enriched in gene expression signatures derive...
ORGANISM(S): Mus musculus 
2011-08-14 | E-GEOD-27101 | biostudies-arrayexpress
TranscriptomicsTumor grafts derived from patients with head and neck squamous carcinoma.
Head and neck squamous cell carcinoma (HNSCC) is a deadly and disfiguring disease for which better systemic therapy is desperately needed. The development of new therapies for HNSCC and the understanding of its biology both depend upon clinically relevant animal models. An increasingly promising x...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-45153 | biostudies-arrayexpress
TranscriptomicsPrimary tumor grafts as advanced models for breast cancer that authentically reflect tumor histopathology, growth, metastasis, and patient outcomes (copy number)
Development and pre-clinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis, in the form of transplantable tumors derived directly from indi...
ORGANISM(S): Homo sapiens 
2011-10-22 | E-GEOD-32530 | biostudies-arrayexpress
TranscriptomicsRNA sequencing investigating the role of TNC in tumor progression using FVB TNC WT and TNC KO mice grafted with NT193 shC cells or NT193 shTNC cells
MMTV-NeuNT transgenic mouse model harbors an activated form of Neu (NeuNT). Mice develop stochastically multifocal mammary adenocarcinomas that metastasize to the lung (Muller et al., 1988). MMTV-NeuNT mouse model exhibits both intravascular and parenchymal metastasis which provides a good tool t...
ORGANISM(S): Mus musculus 
2021-03-25 | E-MTAB-10135 | biostudies-arrayexpress
TranscriptomicsPatient-derived tumor grafts authentically reflect tumor pathology, growth, metastasis, and disease outcomes (expression)
Development and pre-clinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis, in the form of transplantable tumors derived directly from indi...
ORGANISM(S): Homo sapiens 
2011-10-22 | E-GEOD-32531 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumor-initiating cells
Using a syngeneic p53 null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified by limiting dilution transplantation as well as in vitro mammosphere and clonogenic assays a Lin-CD29HighCD24High subpopulation of tumor-initiating cells. Differentially expressed ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8863 | biostudies-arrayexpress
TranscriptomicsTenascin-C shapes TRAIL control over tumor immunity
TRAIL cytotoxicity is exploited as anti-cancer therapy since many years, however incomplete knowledge is generating many obstacles. Here, we address whether the highly abundant extracellular matrix molecule tenascin-C (TNC) orchestrating an immune suppressive tumor microenvironment and binding TRAIL...
ORGANISM(S): Mus musculus 
2024-05-30 | E-MTAB-14089 | biostudies-arrayexpress
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
TranscriptomicsAn Animal Model of Myc-driven medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of this subtype of the disease. Here we show that cerebellar s...
ORGANISM(S): Mus musculus 
2011-12-05 | E-GEOD-34126 | biostudies-arrayexpress
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