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ProteomicsSyntenin inhibition impairs stroma-tumor communication in Multiple Myeloma and improves Bortezomib treatment efficiency
In multiple myeloma, the objective is to assess the impact of syntenin knockout on the secretory profile of bone marrow stromal cells using the HS-5 model.
ORGANISM(S): Homo sapiens (Human) 
2025-07-26 | PXD064458 | Pride
Lc-msms Multiple myeloma Tumor stroma communication Syntenin inhibition Secretome 
TranscriptomicsExpression Data from Normal or Tumor Fibroblasts With or Without Ets2
The mechanisms involved in epithelium-stroma interactions remain poorly understood, despite the importance of the microenvironment during tumorigenesis. Here, we studied the role of the Ets2 transcription factor in tumor-associated fibroblasts in the MMTV-PyMT mammary tumor model. Inactivation of ...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-16989 | biostudies-arrayexpress
GenomicsTargeting tumor-stroma communication by blocking endothelin-1 receptor signaling sensitizes high-grade serous ovarian cancer to PARP inhibitor
Targeting tumor-stroma communication by blocking endothelin-1 receptor signaling sensitizes high-grade serous ovarian cancer to PARP inhibitor
PRJNA803193 | ENA
UnknownTargeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition.
Not available
S-EPMC9816119 | biostudies-literature
UnknownHuman mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism.
Not available
S-EPMC11488203 | biostudies-literature
GenomicsTumor-derived lactic acid modulates activation and metabolic status of draining lymph node stroma
Tumor-derived lactic acid modulates activation and metabolic status of draining lymph node stroma
PRJNA763916 | ENA
TranscriptomicsCellular adhesion promotes prostate cancer cells escape from dormancy
Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, following initial treatment, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as tumor dormancy. Iden...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-64262 | biostudies-arrayexpress
UnknownPAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy.
Not available
S-EPMC9978919 | biostudies-literature
TranscriptomicsTranscriptomic profiling of pancreatic stellate cells and pancreatic cancer cells in a gemcitabine-driven tumor-stroma supernatant transfer model
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive tumor-stroma interactions that influence disease progression and therapy response. To investigate transcriptional changes associated with chemotherapy-induced tumor-stroma signaling, RNA sequencing was performed in a supernatant t...
ORGANISM(S): Mus musculus 
2026-03-18 | GSE324779 | GEO
TranscriptomicsTargeting tumor-stroma communication by blocking endothelin-1 receptor signaling sensitizes high-grade serous ovarian cancer to PARP inhibitor
High-grade serous ovarian cancer (HG-SOC), characterized by very frequent mutations in TP53 gene, is a highly lethal cancer and is refractory to therapeutic strategies. In HG-SOC, the reciprocal signal exchange between tumor cells and various types of stromal elements from the tumor microenvironment...
ORGANISM(S): Homo sapiens 
2023-01-11 | GSE196065 | GEO
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