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TranscriptomicsCD8+ Tumor-Infiltrating Lymphocyte Abundance is a Positive Prognostic Indicator in Nasopharyngeal Cancer
A retrospective tissue study to explore the prognostic significance of tumor-infiltrating lymphocyte (TIL) populations in Nasopharyngeal Cancer, using a combination of RNA sequencing and immunohistochemistry.
ORGANISM(S): Homo sapiens 
2022-09-01 | E-MTAB-11963 | biostudies-arrayexpress
TranscriptomicsCD8+/CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients
We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T-cell distribution and functions, and the prognosis significance of ...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-MTAB-3266 | biostudies-arrayexpress
MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
TranscriptomicsNon-cancerous liver infiltrating lymphocytes of hepatitis C and tumor-infiltrating lymphocytes
Study goal is to disclose features of gene expressio profile of non-cancerous liver-infiltrating lymphocytes of type C hepatitis patients with hepatocellular carcinomas and tumor-infiltrating lymphocytes of type C hepatitis patients with hepatocellular carcinomas. Keywords: gene expression profile,...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10461 | biostudies-arrayexpress
ProteomicsProteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
Tumors that contain tumor-infiltrating lymphocytes (TIL) with tissue-resident memory T cells (TRM) features are associated with better patient prognoses. While CD8+ T cells that target tumors often fail to restrain tumor growth due to progressive T cell exhaustion, pathogen-specific TRM survey tissu...
ORGANISM(S): Homo sapiens (Human) 
2026-04-30 | PXD067417 | Pride
Cancer Tumor-infiltrating lymphocyte Cd8+ t cell E3 ubiquitin ligase Immunotherapy Tumor Proteostasis 
ProteomicsProteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
Tumors that contain tumor-infiltrating lymphocytes (TIL) with tissue-resident memory T cells (TRM) features are associated with better patient prognoses. While CD8+ T cells that target tumors often fail to restrain tumor growth due to progressive T cell exhaustion, pathogen-specific TRM survey tissu...
ORGANISM(S): Homo sapiens (Human) 
2026-04-21 | PXD063865 | Pride
Cancer Tumor-infiltrating lymphocyte Cd8+ t cell E3 ubiquitin ligase Immunotherapy Tumor Proteostasis 
TranscriptomicsTranscription profiling of human T cell lines isolated from tumor infiltrating lymphocytes or peripheral blood lymphocytes of a patient with large cell carcinoma of the lung
The IGR-Heu tumor cell line was established from patient Heu suffering from large cell carcinoma of the lung. Heu171, Heu127 and Heu161 T cell clones were isolated from autologous tumor infiltrating lymphocytes. H32 T cell line and H32-22 clone were isolated from autologous PBL after stimulation wit...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-TABM-208 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T cell lines isolated from tumor infiltrating lymphocytes or peripheral blood lymphocytes of a patient with large cell carcinoma of the lung
The IGR-Heu tumor cell line was established from patient Heu suffering from large cell carcinoma of the lung. Heu171 T cell clones were isolated from autologous tumor infiltrating lymphocytes. H32-22 clone was isolated from autologous peripheral blood lymphocytes after stimulation with IGR-Heu and...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-TABM-207 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling of Tumor-Infiltrating Lymphocyte-Mediated Cytotoxicity against Patient-Derived Lung Cancer Organoids
Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality, and therapies utilizing tumor-infiltrating lymphocytes (TILs) show significant promise. However, the molecular signatures that define a productive TIL-mediated response against tumors remain poorly characterized. Here, we est...
ORGANISM(S): Thermoplasma acidophilum DSM 1728 
2025-10-31 | E-MTAB-15782 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling of Tumor-Infiltrating Lymphocyte-Mediated Cytotoxicity against Patient-Derived Lung Cancer Organoids
Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality, and therapies utilizing tumor-infiltrating lymphocytes (TILs) show significant promise. However, the molecular signatures that define a productive TIL-mediated response against tumors remain poorly characterized. Here, we est...
ORGANISM(S): Homo sapiens 
2025-10-26 | E-MTAB-15784 | biostudies-arrayexpress
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