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TranscriptomicsTranscription profiling of mouse with human solid tumors eradicated with an intravenously injected light-emitting oncolytic Vaccinia virus
Previously we reported that a recombinant vaccinia virus (VACV) carrying a light-emitting fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new recombinant VACV, GLV-1h68, as a simultaneous diagnostic and therapeutic agent, was constructed by inserting three expressio...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8513 | biostudies-arrayexpress
ProteomicsTumor-targeting and cytokine-armed vaccinia virus promotes cytotoxicity towards pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells.
Pancreatic ductal adenocarcinoma (PDAC) remains a particularly aggressive disease with few effective treatments. The PDAC tumor immune microenvironment (TIME) has been characterized as immune suppressed. Oncolytic viruses can increase tumor antigenicity via immunogenic cell death (ICD). In this stud...
ORGANISM(S): Homo sapiens (Human) 
2024-09-20 | PXD048276 | Pride
Tmt Natural killer cells Human Immunogenic cell death Tumor-targeting vaccinia virus Phosphorylation Immune modulation Global proteome 
UnknownVaccinia virus-based vector against infectious diseases and tumors.
Not available
S-EPMC8115763 | biostudies-literature
UnknownTargeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma.
Not available
S-EPMC1142116 | biostudies-literature
UnknownNovel immune checkpoint inhibitor FilC/PD-1 recombinant vaccinia virus inhibits hepatocellular carcinoma.
Not available
S-EPMC12450999 | biostudies-literature
TranscriptomicsEradication of Solid Human Tumors in Nude Mice with an Intravenously Injected Light-Emitting Oncolytic Vaccinia Virus
Previously we reported that a recombinant vaccinia virus (VACV) carrying a light-emitting fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new recombinant VACV, GLV-1h68, as a simultaneous diagnostic and therapeutic agent, was constructed by inserting three expressio...
ORGANISM(S): Mus musculus 
2007-12-26 | GSE8513 | GEO
UnknownAntiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models.
Not available
S-EPMC2798339 | biostudies-literature
UnknownDesign Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy.
Not available
S-EPMC9504998 | biostudies-literature
UnknownTransient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus.
Not available
S-EPMC7210704 | biostudies-literature
UnknownRedirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene.
Not available
S-EPMC9114156 | biostudies-literature
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