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The intestinal microbiota modulates colon cancer tumorogenesis
We performed high-throughput RNA sequencing of stable lines with dox-inducible expression of sh-mirE-YAP or of the constitutively nuclear YAPS127A mutant to investigate YAP dependency and its role in tumorogenesis.
ORGANISM(S): Homo sapiens 
2023-03-09 | GSE198379 | GEO
Chemoresistance induced by cisplatin application hinders the clinical outcomes of chemotherapy and needs resolving, hence we sought to find its modulating role in tumorogenesis or drug resistance between human lung adenocarcinoma cancer cell line A549 and its chemoresistant cell line A549/DDP.
ORGANISM(S): Homo sapiens 
2020-11-18 | GSE154243 | GEO
Chemoresistance induced by upregulated ZNF300 in A549/DDP, which was established with a low dosage of cisplatin treatment previously, was in clinical need of resolving. Because ZNF300 was selected as a regulator in associated with drug resisance, we sought to find its modulating role in tumorogenesi...
ORGANISM(S): Homo sapiens 
2020-11-18 | GSE145880 | GEO
The contribution of aberrant DNA methylation and the downstream effects in tumorogenesis through silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations can be reversed, we investigated the effects of the epigenetic therapy in breast cancer ...
ORGANISM(S): Homo sapiens 
2012-01-24 | GSE28968 | GEO
The contribution of aberrant DNA methylation and the downstream effects in tumorogenesis through silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations can be reversed, we investigated the effects of the epigenetic therapy in breast cancer ...
ORGANISM(S): Homo sapiens synthetic construct 
2012-01-24 | GSE28969 | GEO
We have reported that pulmonary infiltrating macrophages, which highly express inducible nitric-oxide synthase (iNOS/NOS2), play a critical role for driving spontaneous lung SCC development in a new mouse model (L-Ikka KA/KA; KA/KA) that mimics human lung SCC development. However, the role of NOS2 i...
ORGANISM(S): Mus musculus 
2017-07-22 | GSE101759 | GEO
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