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To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
Low-protein diets (LPD) have been linked to improved metabolic health, but their role in pancreatic ductal adenocarcinoma (PDAC) immunotherapy remains unclear. Here we show that an LPD suppresses PDAC progression in male mice by remodeling the gut microbiota and activating anti-tumor immunity. LPD p...
2026-07-09 | MTBLS14989 | MetaboLights
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
Autophagy Suppresses CD8+ T cell Anti-tumour Immunity
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
Interleukin-4 modulates type I interferon to augment anti-tumour immunity
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation.
The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity
Interleukin-4 modulates type I interferon to augment anti-tumour immunity [scRNA-Seq]
Micropeptide UEIS attenuates cGAS-STING-type I IFN signalling to repress anti-tumour immunity
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