Tumour-suppressor protein

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Transcriptomics (1876)
Unknown (951)
Genomics (320)
Proteomics (99)
Metabolomics (14)
Other (4)
Models (3)
Methylation profiling (3)
Clinical (1)
Multiomics (1)

Organisms

Homo sapiens (1336)
Mus musculus (562)
Rattus norvegicus (35)
Drosophila melanogaster (19)
Arabidopsis thaliana (17)
Saccharomyces cerevisiae (16)
Gallus gallus (10)
Sus scrofa (9)
Bos taurus (6)
Danio rerio (6)
Caenorhabditis elegans (5)
Buchnera aphidicola (3)
Schizosaccharomyces pombe (3)
Mycobacterium tuberculosis (3)
Salmo salar (3)
Solanum lycopersicum (3)
Canis lupus familiaris (3)
human lung metagenome (2)
Gossypium hirsutum (2)
Populus trichocarpa x Populus deltoides (2)
Ciona intestinalis (2)
Macaca mulatta (2)
Pan paniscus (2)
Zea mays (2)
Oryza sativa (2)
Vitis vinifera (2)
Bacillus subtilis (2)
Streptococcus pneumoniae (2)
Pseudomonas aeruginosa PAO1 (2)
Mammalia (1)

Organisms

Homo sapiens (76)
Mus musculus (14)
Drosophila melanogaster (4)
Saccharomyces cerevisiae BY4741 (1)
Danio rerio (1)

Repository

biostudies-arrayexpress (1944)
ENA (102)
geo (96)
EGA (71)
pride (51)
MassIVE (25)
jPOST (12)
MetaboLights (12)
BioModels (3)
iProX (3)
GNPS (2)
GPMDB (1)
PeptideAtlas (1)

Tissue

Cell culture (17)
Epithelial cell (9)
Fibroblast (4)
Embryonic stem cell (3)
HeLa cell (3)
Breast (2)
Colon (2)
Female Reproductive System (1)
Blood (1)
Cholangiocyte (1)
Early embryonic cell (1)
Embryo (1)
Embryonic fibroblast (1)
Liver (1)
Malignant cell (1)
Melanocyte (1)
Ovarian surface epithelial cell (1)
Permanent cell line cell (1)
Plasma cell (1)
Prostate cancer cell line (1)
Stem cell (1)

Disease

Normal (13)
Breast cancer (10)
Glioblastoma (5)
Colon cancer (5)
Colorectal cancer (4)
Prostate carcinoma (3)
Tumour (2)
Pre-diabetic (2)
Glioblastoma multiforme (2)
Tumor (2)
Central nervous system cancer (2)
Invasive ductal carcinoma (2)
Neuroblastoma (2)
Ovarian cancer patient invasive malignant (1)
4T1 tumor-bearing (1)
LPS-induced acute lung injury (1)
Normal renal cortex (1)
Acute lymphocytic leukemia (1)
Intestinal type gastric cancer (1)
Hepatomegaly (1)
Locally advanced breast carcinoma (LABC; non-inflammatory) (1)
Large cell carcinoma (1)
Perilobar nephrogenic rest (1)
Extranodal NK/T-Cell Lymphoma derived cell line (1)
Asthma (1)
Myelogenous leukaemia (1)
Lymphoma (1)
Phyllodes tumor (1)
Unclassified carcinoid (1)
Gliosarcoma (1)

Technology Type

Mass Spectrometry (51)
Shotgun proteomics (22)
Bottom-up proteomics (13)
Affinity purification coupled with mass spectrometry proteomics (12)
Mass spectrometry (11)
Data-dependent acquisition (9)
Illumina HiSeq 2000 (5)
Chemical cross-linking coupled with mass spectrometry proteomics (3)
Illumina HiSeq 2500, ILLUMINA (2)
Illumina HiSeq 2500 (2)
ILLUMINA, Illumina HiSeq 2500 (1)
HiSeq X Ten, ILLUMINA (1)
AB SOLiD System 3.0 (1)
Mass spectrometry assay (1)
Data-independent acquisition (1)
Gel-based experiment (1)

Instrument Platform

Illumina NovaSeq 6000 (42)
Illumina HiSeq 2500 (34)
Illumina HiSeq 4000 (32)
Illumina HiSeq 2000 (28)
NextSeq 500 (26)
NextSeq 550 (8)
Illumina Genome Analyzer IIx (7)
Axon GenePix 4000B scanning hardware (6)
GenePix 4000B [Axon Instruments] (5)
Illumina MiSeq (5)
Illumina Genome Analyzer II (3)
Scanning hardware (3)
HiSeq X Ten (3)
Illumina HiSeq 1500 (3)
Illumina HiSeq 3000 (3)
Illumina HiSeq (2)
Agilent G2565AA and G2565BA Microarray Scanner (2)
Chemostat (2)
Axon- GenePix4000B (2)
NextSeq 2000 (2)
D1000 ScreenTape Analysis, Qubit Fluorometer. (1)
Mastercycler pro S Thermocyler (Eppendorf); 2100 Bioanalyzer (Agilent) (1)
2100 Bioanalyzer (Agilent); Axio Imager.Z2 (ZEISS) (1)
CryoStar NX70 Cryostat (Epredia) (1)
PromethION (1)
Covaris (1)
Bio-Rad CFX96 Real-time System (1)
BD LSRFortessa (1)
MACS Whole Skin Dissociation Kit (1)
GenePix 4200A (1)

Publication Date

2012 (244)
2014 (242)
2013 (232)
2011 (204)
2010 (202)
2016 (159)
2015 (153)
2008 (102)
2009 (82)
2017 (58)
2023 (53)
2026 (50)
2024 (49)
2021 (48)
2022 (46)
2007 (46)
2019 (35)
2018 (32)
2006 (31)
2020 (28)
2005 (20)
2025 (9)
2004 (8)
2003 (2)

UNIPROT ID/AC

P24941 (3)
P24864 (3)
P38936 (2)
P04637 (2)
Q08999 (1)
Q9NZJ0 (1)
Q13309 (1)
P12004 (1)
P78396 (1)
Q01094 (1)
P24385 (1)
P11802 (1)
A0A024R563 (1)
A0A024R8H9 (1)
A0A024RAN2 (1)
A0A024RC46 (1)
A0A075B6P5 (1)
A0A087WT59 (1)
A0A087WTX5 (1)
A0A087WUD1 (1)
A0A087WVW2 (1)
A0A087WVZ5 (1)
A0A087WWA5 (1)
A0A087WWK8 (1)
A0A087WXI0 (1)
A0A087WYL9 (1)
A0A087WZE9 (1)
A0A087X130 (1)
A0A087X1S3 (1)
A0A087X1V9 (1)

ENSEMBL ID

ENSG00000147251 (1)
ENSG00000170477 (1)
ENSG00000204131 (1)
ENSG00000229353 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:29016 (5)
CHEBI:16919 (5)
CHEBI:15354 (5)
CHEBI:75062 (4)
CHEBI:17768 (4)
CHEBI:16610 (4)
CHEBI:22660 (4)
CHEBI:18237 (4)
CHEBI:17154 (4)
CHEBI:16811 (4)
CHEBI:17126 (4)
CHEBI:16040 (4)
CHEBI:25017 (4)
CHEBI:17012 (4)
CHEBI:17310 (4)
CHEBI:16335 (4)
CHEBI:17562 (4)
CHEBI:17361 (4)
CHEBI:16393 (4)
CHEBI:26271 (4)
CHEBI:17345 (4)
CHEBI:16027 (4)
CHEBI:16695 (4)
CHEBI:47867 (1)
CHEBI:16595 (1)
CHEBI:29108 (1)
CHEBI:16991 (1)
CHEBI:16541 (1)
CHEBI:33699 (1)
CHEBI:15422 (1)

Metabolite Name

AMP (4)
L-Tryptophan (4)
Sphingosine (3)
N-acetylneuraminate (3)
N-acetylcitrulline (3)
N-acetylarginine (3)
Gamma-glutamylglutamate (3)
Deoxycarnitine (3)
4-guanidinobutanoate (3)
Oleoyl ethanolamide (3)
Cytosine (3)
Cytidine (3)
Thiamine (3)
ADP (3)
Hydrocortisone (3)
Pyridoxine (3)
Choline (3)
Taurine (3)
Adenosine (3)
Maltotriose (3)
Glutaric acid (3)
Pyridoxal (3)
Linoleic acid (3)
Creatine (3)
L-Tyrosine (3)
D-(+)-Galactosamine (2)
Mebeverine (2)
2-palmitoleoyl-GPC* (16:1)* (2)
Folic acid (2)
Prolylhydroxyproline (2)

First Public Date

2026 (30)
2017 (15)
2014 (14)
2023 (6)
2021 (6)
2016 (6)
2015 (6)
2024 (5)
2025 (4)
2020 (4)
2022 (3)
2019 (2)
2013 (1)

Modelling Approach

Ordinary differential equation model (3)

Study status

Not provided (1)

Lab affiliation

Imperial College London (6)
Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia (2)
(1) Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK; (2) Leibniz-Institute für Analytische Wissenschaften-ISAS- e.V., Dortmund, Germany (1)
Associate Professor, Department of biotechnology and research, Sir Ganga ram hospital, New Delhi -110060, Delhi, India (1)
Biology Department University of Massachusetts Boston Boston, USA (1)
CABIMER University of Sevilla SPAIN (1)
CRG, UPF (1)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS) (1)
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. (1)
Centre for Genomics and Computational Biology. Barts Cancer Institute / Queen Mary University of London (1)
Department of Biochemistry, Ghent University, Belgium (1)
Department of Cell Biology, Harvard Medical School, Boston, USA (1)
Department of Gene Regulation Friedrich Miescher Institute for Biomedical Research (1)
Department of Gene Regulation Friedrich Miescher Institutefor Biomedical Research (1)
Department of Medicine and Life Sciences, Pompeu Fabra University, 08003, Barcelona, Spain. (1)
Dept. of Oncology, University of Oxford, Oxford, OX3 7DQ, UK (1)
Functional Proteomics, ICR (1)
Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, The Netherlands (1)
INGM, Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi", Milan, Italy. (1)
Institute of Cancer Research, London (1)
Instituto de Investigaciones Sanitarias de Santiago de Compostela (1)
Karolinska Institutet, Stockholm, Sweden (1)
Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen 518172, China. (1)
Laboratory of Cancer Cell Biology Institute of Molecular Genetics of the Czech Academy of Sciences Prague Czech Republic (1)
Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences Vídeňská 1083, 142 20 Prague 4, Czech Republic (1)
Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. (1)
MRC Toxicology Unit, University of Cambridge (1)
Manager Biological Mass Spectrometry Core Dalhousie University (1)
Max Planck Institute for Molecular Biomedicine Bioanalytical Mass Spectrometry Unit Röntgenstr. 20 48149 Münster Germany (1)

IsPrivate

False (3)

Modification

Not available (1)

Study type

Transcription profiling by array (1181)
RNA-seq of coding RNA (167)
Comparative genomic hybridization by array (109)
ChIP-seq (88)
Methylation profiling by array (67)
RNA-seq of non coding RNA (31)
RNA-seq of coding RNA from single cells (30)
ChIP-chip by tiling array (28)
Other (28)
ChIP-chip by array (24)
Unknown experiment type (22)
Genotyping by array (21)
MicroRNA profiling by array (21)
Methylation profiling by high throughput sequencing (18)
DNA-seq (17)
Transcription profiling by RT-PCR (12)
RNA-seq of total RNA (7)
Cell line - High-throughput sequencing (6)
Proteomic profiling by array (6)
Animal - High-throughput sequencing (5)
RNAi profiling by array (5)
Human - High-throughput sequencing (4)
MicroRNA profiling by high throughput sequencing (4)
ATAC-seq (4)
RNA-seq of non coding RNA from single cells (3)
Cell line - One-color microarray (3)
Spatial transcriptomics by high-throughput sequencing (3)
Transcription profiling by SAGE (2)
Cell line - Two-color microarray (2)
Human - Methylation microarray (2)

Release Date

2014 (296)
2012 (280)
2013 (267)
2010 (229)
2011 (226)
2016 (211)
2015 (205)
2008 (121)
2017 (112)
2023 (110)
2022 (106)
2009 (104)
2020 (98)
2021 (94)
2019 (83)
2018 (69)
2024 (66)
2007 (53)
2006 (52)
2025 (33)
2005 (29)
2026 (21)
2004 (14)
2003 (6)
2002 (6)
2000 (2)
1997 (2)

Location

Denmark (1)

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Functional characterisation of tumour suppressor PDCD4 reveals a previously undisclosed role in the control of cell adhesion

PDCD4 is a multifunctional RNA binding protein which has tumour suppressor function. To more fully understand how dysregulation of this protein contributes to carcinogenesis we have carried out a comprehensive analysis of the role of PDCD4 in RNA metabolism in untransformed epithelial cells. We show...

ORGANISM(S): Homo sapiens (Human)

2024-07-31 | PXD054188 | Pride