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TranscriptomicsComparative genomic hybridization of 17 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
We have carried out microarray-based comparative genomic hybridisation (arrayCGH) on 17 Favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome. Tumour DNA was co-hybridised with normal female genomic D...
ORGANISM(S): Homo sapiens 
2006-05-11 | E-TABM-13 | biostudies-arrayexpress
MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
TranscriptomicsComparative genomic hybridization of 100 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
We have carried out microarray-based comparative genomic hybridisation (arrayCGH) on 100 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome. Tumour DNA was co-hybridised with normal female genomic ...
ORGANISM(S): Homo sapiens 
2006-05-11 | E-TABM-10 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of colorectal cancer
We profile single cells from patients with colorectum cancer using Chromium 3’ and 5’ single-cell RNA-sequencing. Patients EXT001, EXT009, and EXT012 from the KUL dataset were first analyzed by Lee et al., 2020, and the raw data are available in ArrayExpress under the accession codes E-MTAB-8410 and...
ORGANISM(S): Homo sapiens 
2022-09-16 | E-MTAB-9934 | biostudies-arrayexpress
TranscriptomicsDownregulation of three tumour suppressor genes SLC26A3, DCN and TPM1 in colorectal cancer
Despite identification of major genes and pathways involved in development of colorectal cancer (CRC) it became obvious that several steps in these pathways might be bypassed by other yet unknown genetic events that lead towards CRC. To improve our understanding of the genetic mechanisms of CRC deve...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-14010 | biostudies-arrayexpress
TranscriptomicsTesticular germ cell tumour cells release microRNA containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment
Malignant germ-cell-tumours (GCTs) are characterised by microRNA (miRNA/miR-) dysregulation, with universal over-expression of miR-371~373 and miR-302/367 clusters regardless of patient age, tumour site, or subtype (seminoma/yolk-sac-tumour/embryonal carcinoma). These miRNAs are released into the bl...
ORGANISM(S): Homo sapiens 
2023-09-30 | E-MTAB-13322 | biostudies-arrayexpress
MetabolomicsRegional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues

Cancer, including head and neck squamous cell carcinoma (HNSCC), induces changes to metabolism that drive the disease. Regional metabolomics can help to understand metabolic variation across the tumour including changes near the tumour core, where hypoxia is likely more pronounced. We apply ultra...

2026-06-03 | MTBLS1905 | MetaboLights
MetabolomicsCharacterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights
ModelsLolas2016 - tumour-induced neoneurogenesis and perineural tumour growth
The paper describes a model of tumour-induced neoneurogenesis and perineural tumour growth. Created by COPASI 4.25 (Build 207) This model is described in the article: Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach Georgios Lolas, Arianna Bianchi and Konstant...
2024-09-02 | BIOMD0000000750 | BioModels
ProteomicsA mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
SWATH-MS enables accurate and reproducible label-free quantification of proteomes including in extensively studied model organisms such as the mouse. Here we present a comprehensive mouse reference spectral library (MouseRefSWATH) that allows quantification of up to 10,597 proteins (62.2% of mouse p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-23 | PXD017209 | Pride
Swath-ms  breast cancer  dcis  mouse  human  xenograft model 
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