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MetabolomicsGut microbiota carcinogen metabolism causes distal tissue tumours

Exposure to environmental pollutants and human microbiome composition are important predisposition factors for tumour development. Similar to drug molecules, pollutants are typically metabolised in the body, which can change their carcinogenic potential and impact tissue distribution through alte...

2024-06-05 | MTBLS3581 | MetaboLights
MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
TranscriptomicsTranscription profiling by array of human CYLD defective skin tumours and perilesional skin
Comparison of transcriptomes between CYLD defective skin tumours and perilesional skin
ORGANISM(S): Homo sapiens 
2011-08-16 | E-MTAB-352 | biostudies-arrayexpress
ProteomicsPeptidomic analysis of pancreatic neurodendocrine tumours (Glucagonoma)
A peptidomic analysis of plasma from patients with well characterised pancreatic neuroendocrine tumours (PNET) was performed. A nano LC-MS analysis identified a number of peptides from the glucagon gene, which were idenfiried in a previous case study using multiple immunoassays. Peptides to other pr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082880 | MassIVE
TranscriptomicsMolecular characterisation of soft tissue tumours: a gene expression study
Soft-tissue tumours are derived from mesenchymal cells such as fibroblasts, muscle cells, or adipocytes, but for many such tumours the histogenesis is controversial. We aimed to start molecular characterisation of these rare neoplasms and to do a genome-wide search for new diagnostic markers. We ana...
ORGANISM(S): Homo sapiens 
2005-10-13 | E-GEOD-3443 | biostudies-arrayexpress
TranscriptomicsExpression data as part of an Integrated analysis of oligodendroglial tumours
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net: Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups are currently distinguished based on the IDH mutation and the 1p/19q co-deletion....
ORGANISM(S): Homo sapiens 
2016-03-11 | E-MTAB-3892 | biostudies-arrayexpress
TranscriptomicsMethylation data as part of an Integrated analysis of oligodendroglial tumours
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net: Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups are currently distinguished based on the IDH mutation and the 1p/19q co-deletion....
ORGANISM(S): Homo sapiens 
2016-03-11 | E-MTAB-3903 | biostudies-arrayexpress
TranscriptomicsEffect of enforced BMP4 expression on gene expression profile of 4T1.2 whole primary murine mammary tumours
BMP4 is down-regulated in metastatic human and murine mammary tumours. Here we determined the effect of ectopic mouse Bmp4 re-expression on global gene expression patterns in orthotopic primary mammary tumours in syngeneic Balb/c mice. Breast cancer is a major cause of cancer related death in women,...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-51632 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gastrointestinal stromal tumours according to KIT mutations and expression
Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in KIT or PDGFRA of the type III receptor tyrosine kinase family. Although mutations in either receptor are thought to drive an early oncogenic event ...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-17743 | biostudies-arrayexpress
TranscriptomicsNotch targets stem-cell and temporal-programming genes to orchestrate neuroblast tumours
Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyper-activatio...
ORGANISM(S): Drosophila melanogaster 
2016-10-18 | E-MTAB-3561 | biostudies-arrayexpress
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