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TranscriptomicsRNA-seq of human adipose-derived mesenchymal stem cells cultured in hypoxia against normoxia controls, and human tympanic membrane keratinocytes
Human adipose-derived mesenchymal stem cells were cultured either in hypoxia (Hx; <0.1% oxygen) or standard culture conditions (normoxia, Nx) over 48 hours in serum-free medium. Human tympanic membrane keratinocytes were cultured in standard culture conditions over 48 hours in serum-free medium.
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-9979 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles of 30 tissues from a 112 year old woman
The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of these tissues. Toward this end, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10...
ORGANISM(S): Homo sapiens 
2015-06-03 | E-GEOD-64491 | biostudies-arrayexpress
TranscriptomicsHypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expression but conserved pathways
We have addressed the question of how different rodent species cope with the life-threatening homeostatic challenge of dehydration at the level of transcriptome modulation in the supraoptic nucleus (SON), a specialised hypothalamic neurosecretory apparatus responsible for the production of the antid...
ORGANISM(S): Mus musculus 
2010-11-29 | E-GEOD-25574 | biostudies-arrayexpress
TranscriptomicsB. thailandensis genes induced by subinhibitory concentration of glyphosate
Total transcript amplification (TTA) from single eukaryotic cells for transcriptome analysis is established, but TTA from a single prokaryotic cell presents additional challenges with much less starting material and lack of poly(A)-tails. We described, here, a novel method for single bacterium TTA, ...
ORGANISM(S): Burkholderia thailandensis 
2010-08-05 | E-GEOD-23419 | biostudies-arrayexpress
UnknownPerception of E-health Technology Scale in Chinese Brief (PETS-C Brief): Translation, item reduction, and psychometric testing.
Not available
S-EPMC9500267 | biostudies-literature
GenomicsProgram specificity for Ptf1a in PancreasM-BM- versusM-BM- Neural Tube DevelopmentM-BM- correlates with distinctM-BM- collaborating cofactors and chromatin accessibility
Ptf1a is a lineage-specific basic-helix-loop-helix transcription factor critical in the development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies f...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-47459 | biostudies-arrayexpress
UnknownActivation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.
Not available
S-EPMC8149812 | biostudies-literature
TranscriptomicsPervasive effects of aging on gene expression in wild wolves
We sequenced total RNA from whole blood samples of 27 wild gray wolves from Yellowstone National Park. Gene expression level analysis of both male and female wolves, ranging from ages 0.8-8.8 years.
ORGANISM(S): Canis lupus 
2016-07-27 | E-GEOD-80440 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles of human bone samples
The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of human bone tissue and to relate it to chronological age. Toward this end, we used the epigenetic clock software described in Horvath S (2013) DNA methylation age of human tissues and cell types. Genom...
ORGANISM(S): Homo sapiens 
2015-06-03 | E-GEOD-64490 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles of human brain tissue samples
The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of human tissues and to relate it to chronological age. Toward this end, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome ...
ORGANISM(S): Homo sapiens 
2015-06-03 | E-GEOD-64509 | biostudies-arrayexpress
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