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TranscriptomicsTranscription profiling of mouse with txnrd1 specifically disrupted in all parenchymal hepatocytes - reveals cytoprotective Nrf2 pathway is induced in chronically Txnrd1-deficient hepatocytes
Metabolically active cells require robust mechanisms to combat oxidative stress. The cytoplasmic thioredoxin reductase/thioredoxin (Txnrd1/Txn1) system maintains reduced protein dithiols and provides electrons to some cellular reductases, including peroxiredoxins. Here we generated mice in which th...
ORGANISM(S): Mus musculus 
2009-06-24 | E-GEOD-16381 | biostudies-arrayexpress
TranscriptomicsShifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were ...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-37874 | biostudies-arrayexpress
GenomicsTXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation I
TXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation I
PRJNA836900 | ENA
TranscriptomicsCytoprotective Nrf2 pathway is induced in chronically Txnrd1-deficient hepatocytes
Metabolically active cells require robust mechanisms to combat oxidative stress. The cytoplasmic thioredoxin reductase/thioredoxin (Txnrd1/Txn1) system maintains reduced protein dithiols and provides electrons to some cellular reductases, including peroxiredoxins. Here we generated mice in which the...
ORGANISM(S): Mus musculus 
2009-06-03 | GSE16381 | GEO
GenomicsTXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation II
TXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation II
PRJNA842434 | ENA
GenomicsRNA-seq profiling of TGF-beta induction and TXNRD1 loss in A549 lung cancer cells.
RNA-seq profiling of TGF-beta induction and TXNRD1 loss in A549 lung cancer cells.
PRJNA1401575 | ENA
TranscriptomicsTXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation II
Sterile inflammation, also known as “inflammaging”, is a hallmark of tissue ageing. Cellular senescence contributes to tissue aging in part through secretion of proinflammatory factors known as senescence-associated secretory phenotype (SASP). Thioredoxin reductase 1 (TXNRD1) genetic variability is ...
ORGANISM(S): Mus musculus 
2023-05-25 | GSE204841 | GEO
TranscriptomicsTXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation I
Sterile inflammation, also known as “inflammaging”, is a hallmark of tissue ageing. Cellular senescence contributes to tissue aging in part through secretion of proinflammatory factors known as senescence-associated secretory phenotype (SASP). Thioredoxin reductase 1 (TXNRD1) genetic variability is ...
ORGANISM(S): Homo sapiens 
2023-05-25 | GSE202664 | GEO
TranscriptomicsRNA-seq profiling of TGF-beta induction and TXNRD1 loss in A549 lung cancer cells.
We performed bulk RNA-seq to investigate transcriptional responses to TGF-β1 signaling in A549 human lung adenocarcinoma cells with different TXNRD1 genetic backgrounds. Wild-type A549 cells and TXNRD1-knockdown A549 cells generated by single-guide RNA targeting TXNRD1 (sgTXNRD1) were analyzed under...
ORGANISM(S): Homo sapiens 
2026-09-16 | GSE316125 | GEO
UnknownElovanoid-N34 modulates TXNRD1 key in protection against oxidative stress-related diseases.
Not available
S-EPMC10716158 | biostudies-literature
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