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TranscriptomicsTranscription profiling of human A549 cell line treated with type I and II interferons vs. controls
Type I and type II interferons (IFNs) bind to different cell surface receptors but activate overlapping signal transduction pathways. We examined the effects of a type I IFN (IFN-acon1) and a type II iFN (IFN-g1b) on gene experession in A549 cells and demonstrate that there is a common set of genes ...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-5542 | biostudies-arrayexpress
GenomicsMapping responses to type I interferons
Single-cell analysis of signalling and transcriptional responses to type I interferons
PRJEB60774 | ENA
TranscriptomicsModulation of T cell responses by type I interferons
Type I interferons (IFNs) play a key role in linking the innate and adaptive immune responses. IFNs can have both positive and negative effects on the development of memory CD8+ T cells, but their contribution to the priming of naïve T cells is unclear. Using OT-I TCR transgenic T cells, we show st...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-41381 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD14+ peripheral blood monocytes from HIV patients vs uninfected controls suggest that monocyte function is diminished during high-level HIV viremia and that this effect is mediated by chronic stimulation by type I interferons
The effect of human immunodeficiency virus (HIV) infection and high-level HIV replication on the function of monocytes was investigated. HIV-positive patients had elevated levels of spontaneous production of some or all of the monocyte proinflammatory cytokines measured (interleukin-1beta [IL-1beta]...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5220 | biostudies-arrayexpress
TranscriptomicsInfluence of type I Interferons on function of splenic conventional dendritic cells.
Type I Interferons encompasses a large family of closely related cytokines comprising of at least 13 IFN-α isotypes and single IFN-β. Both IFN-α and IFN-β exert their activity through a common receptor IFNAR. Type I Interferons have broad regulatory effects and various subtypes of dendritic cells ar...
ORGANISM(S): Mus musculus 
2009-07-07 | E-GEOD-12392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of primary human hepatocytes derived from hepatitis C patients treated with type III interferons (IFNs) for 6 or 24 hours
Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III IFNs in intrinsic antiviral immunity is poorly understood. Here we show that HCV infection of primar...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31193 | biostudies-arrayexpress
GenomicsAntiviral function of type I and type III interferons in the olfactory epithelium
Antiviral function of type I and type III interferons in the olfactory epithelium
PRJNA645461 | ENA
GenomicsEffect of type I interferons against HSV infection in cerebral organoids
Effect of type I interferons against HSV infection in cerebral organoids
PRJNA607315 | ENA
GenomicsIKK-epsilon regulates the balance between the type I and type II interferon responses
Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, S...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33913 | biostudies-arrayexpress
GenomicsSetdb1-loss induces type-I interferons and immune clearance of melanoma (scRNA-Seq)
Setdb1-loss induces type-I interferons and immune clearance of melanoma (scRNA-Seq)
PRJNA971948 | ENA
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