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TranscriptomicsTranscriptome in alveolar epithelial type II-like cells differentiated from human lung progenitor cells
Resident stem/progenitor cells in lungs are important for tissue homeostasis and repair. We isolated human lung progenitor cells and named alveolar epithelial progenitor cells (AEPCs)(Fujino N, et al. 2011. Lab Invest. 91:363). AEPCs have phenotypes of both alveolar epithelial type II (ATII) cells a...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-33825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat freshly-isolated alveolar epithelial type I cells, freshly-isolated type II cells, and type II cells cultured for 7 days
Comparison of rat freshly-isolated alveolar epithelial type I cells, freshly-isolated type II cells, and type II cells cultured for 7 days
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1567 | biostudies-arrayexpress
TranscriptomicsPCR array of inflammatory cytokines and receptors in mouse lungs with NF-kappaB RelA mutant in alveolar epithelial cells during LPS stimulation
A murine model of RelA mutated throughout the alveolar epithelium was generated. Mice were anesthetized and intratracheally instilled with 50M-NM-
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-38398 | biostudies-arrayexpress
TranscriptomicsPCR array of inflammatory cytokines and receptors in mouse lungs with NF-kappaB RelA mutant in alveolar epithelial cells during pneumococcal pneumonia
A murine model of RelA mutated throughout the alveolar epithelium was generated. Mice were anesthetized and intratracheally instilled with 106 CFU of Streptococcus pneumoniae serotype 3 into the left lung lobe. Mice were euthanized after 15 hours after instillation, and left lung lobes were collecte...
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-38399 | biostudies-arrayexpress
ProteomicsHuman alveolar hydrogels promote morphological and transcriptional differentiation in iPSC-derived alveolar type 2 epithelial cells
Alveolar type 2 epithelial cells (AT2s) derived from human induced pluripotent stem cells (iAT2s) have rapidly contributed to our understanding of AT2 function and disease. However, as iAT2s are primarily cultured in three-dimensional (3D) Matrigel, a matrix derived from cancerous mouse tissue, it i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-10 | MSV000091470 | MassIVE
TranscriptomicsTranscriptomes of Alveolar epithelial cells
Freshly isolated type I and type II alveolar epithelial cells were investigated for transcriptomes with dual-color DNA microarray using 3DNA 50 kit.
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2160 | biostudies-arrayexpress
ProteomicsQuantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection
We established a new protocol for negative immunomagnetic isolation of murine primary Type II alveolar epithelial cells (AEC II) yielding untouched primary murine AEC II. AEC II were collected from mice 24h after Aspergillus fumigatus or mock infection (9 replicates per experimental group) and analy...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-05 | PXD005834 | Pride
Infection Aspergillus fumigatus Lung Type ii alveolar epithelial cells Aspergillosis Primary cells 
TranscriptomicsTranscription profiling of human fetal lung epithelial cells in undifferentiated state and after type II cell differentiation induced by DCI treatment
Studies of human fetal lung in explant culture and in isolated epithelial cells have demonstrated that both glucocorticoids and cyclic AMP promote differentiated alveolar type II cell phenotype as assessed by ultrastructural morphology and surfactant production. This project profiles changes in gen...
ORGANISM(S): Homo sapiens 
2007-11-22 | E-GEOD-3306 | biostudies-arrayexpress
TranscriptomicsExpression data of influenza A-infected human type I-like alveolar epithelial cells
Pandemic influenza H1N1 (pdmH1N1) virus causes mild disease in humans but occasionally leads to severe complications and even death, especially in those who are pregnant or have underlying disease. Cytokine responses induced by pdmH1N1 viruses in vitro are comparable to other seasonal influenza viru...
ORGANISM(S): Homo sapiens 
2010-10-06 | E-GEOD-24533 | biostudies-arrayexpress
TranscriptomicsExpression Data from Allogeneic Human Mesenchymal Stem Cells and Primary Cultures of Human Alveolar Epithelial Type II Cells
Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a severe syndrome affecting more than 200,000 patients annually in the U.S. New studies are needed to understand the biological and clinical mechanisms that impair alveolar epithelial function. Also, innovative therapies are ...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-68610 | biostudies-arrayexpress
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