Sort   by:  
 Page size 
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
Characteristic for type III CRISPR-Cas systems is the generation of cyclic oligoadenylate (cOA) molecules, which allosterically activate proteins carrying cognate sensory domains: CARF or SAVED. Here, we characterize a type III-B system associated set of genes from Haliangium ochraceum, containing t...
ORGANISM(S): Haliangium ochraceum DSM 14365 
2025-05-06 | PXD046897 | Pride
Quorum sensing represses Type III-A CRISPR-Cas in Staphylococcus aureus by inhibiting SarA and ArcR-mediated activation of cas genes
The involvement of Mycobacterium type III-A CRISPR-Cas system in oxidative stress and intracellular fitness
CRISPR-Cas immunity is repressed by the LysR-type transcriptional regulator PigU
CRISPR-Cas systems in bacteria and archaea provide powerful defense against phages and other foreign genetic elements. The principles of CRISPR-Cas activity are well understood, but less is known about how their expression is regulated. The cyanobacterium Synechocystis sp. PCC 6803 encodes three sep...
ORGANISM(S): Synechocystis sp. (strain PCC 6803 / Kazusa) 
2024-07-15 | PXD047440 | Pride
Previous studies suggest that type I and type II CRISPR-Cas systems were employed to evade host immunity by targeting interference of bacteria’s own genes. Although Mycobacterium bovis (M. bovis) and Mycobacterium tuberculosis (M. tuberculosis) possess integrated type III-A CRISPR-Cas system, its ro...
ORGANISM(S): Mycobacterium tuberculosis variant bovis 
2021-02-05 | GSE166137 | GEO
Sort   by:  
 Page size